4,6-dihydroxy-2-stearyloxyacetophenone | 1246764-90-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4,6-dihydroxy-2-stearyloxyacetophenone
• 英文别名: 1-(2,4-Dihydroxy-6-octadecoxyphenyl)ethanone
• CAS: 1246764-90-8
• 化学式: C₂₆H₄₄O₄
• 分子量: 420.633
• InChiKey: LHIRWFKLBMGVPA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.3
• 重原子数：
  30
• 可旋转键数：
  19
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2,4,6-三羟基苯乙酮一水合物 、 硬脂基溴 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 3.0h， 以3.6%的产率得到2,6-dihydroxy-4-stearyloxyacetophenone
  参考文献：
  名称：

  Prenylflavonoids and prenyl/alkyl-phloroacetophenones: Synthesis and antitumour biological evaluation☆

  摘要：

  Several prenylflavonoids have been synthesised and tested against human tumour cell lines. The prenyl unit has been geranyl or a labdane diterpene. These labdane-flavonoids have been synthesised for the first time. The antitumour activity increase with the prenylation at C-8 position. Twenty-three C and O-prenylated acylphloroglucinols have been synthesised as well. In this case the C-alkylation products have resulted, in general, more active. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.06.025

文献信息

• Prenylflavonoids and prenyl/alkyl-phloroacetophenones: Synthesis and antitumour biological evaluation☆
  作者：P. Basabe、M. de Román、I.S. Marcos、D. Diez、A. Blanco、O. Bodero、F. Mollinedo、B.G. Sierra、J.G. Urones

  DOI：10.1016/j.ejmech.2010.06.025

  日期：2010.9

  Several prenylflavonoids have been synthesised and tested against human tumour cell lines. The prenyl unit has been geranyl or a labdane diterpene. These labdane-flavonoids have been synthesised for the first time. The antitumour activity increase with the prenylation at C-8 position. Twenty-three C and O-prenylated acylphloroglucinols have been synthesised as well. In this case the C-alkylation products have resulted, in general, more active. (C) 2010 Elsevier Masson SAS. All rights reserved.