(S,Z)-2-benzylidene-1-(3-methoxyphenyl)-3-(2-oxo-4-phenyloxazolidin-3-yl)propane-1,3-dione | 1252612-24-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: (S,Z)-2-benzylidene-1-(3-methoxyphenyl)-3-(2-oxo-4-phenyloxazolidin-3-yl)propane-1,3-dione
• CAS: 1252612-24-0
• 化学式: C₂₆H₂₁NO₅
• 分子量: 427.456
• InChiKey: PYVFZEBSJGJXGQ-UAPYWLNTSA-N

物化性质

• 熔点：
  146-148 °C
• 沸点：
  604.9±65.0 °C(predicted)
• 密度：
  1.290±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.68
• 重原子数：
  32.0
• 可旋转键数：
  6.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  72.91
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  (S,Z)-2-benzylidene-1-(3-methoxyphenyl)-3-(2-oxo-4-phenyloxazolidin-3-yl)propane-1,3-dione 在 copper(II) bis(trifluoromethanesulfonate) 作用下， 以 二氯甲烷 为溶剂， 以18%的产率得到(S)-3-[(1S,2R)-5-methoxy-3-oxo-1-phenyl-2,3-dihydro-1H-indene-2-carbonyl]-4-phenyloxazolidin-2-one
  参考文献：
  名称：

  A Reductive-Coupling plus Nazarov Cyclization Sequence in the Asymmetric Synthesis of Five-Membered Carbocycles

  摘要：

  Palladium-mediated hydrostannylation of alkynoyl compounds is combined with Stille-Scott cross-coupling (reductive-coupling) to give one-pot access to divinyl and aryl vinyl ketones, which undergo Nazarov cyclization to give cyclopentenones upon treatment with acid. This reaction sequence has been studied with a variety of different substitution patterns, including the use of oxazolidinone auxiliaries to achieve torquoselectivity in the Nazarov cyclization. Through a combination of good yields and moderate to good levels of stereochemical induction, this approach affords efficient, convergent, and asymmetric access to a variety of different cyclopentanoid systems.

  DOI：

  10.1021/jo100736p
• 作为产物：
  描述：

  间甲氧基苯甲酰氯 、 (4S)-3-(3-phenyl-2-propyonyl)-4-phenyloxazolidin-2-one 在 四(三苯基膦)钯 、 三正丁基氢锡 、 copper(l) chloride 作用下， 以 四氢呋喃 为溶剂， 以79%的产率得到(S,Z)-2-benzylidene-1-(3-methoxyphenyl)-3-(2-oxo-4-phenyloxazolidin-3-yl)propane-1,3-dione
  参考文献：
  名称：

  A Reductive-Coupling plus Nazarov Cyclization Sequence in the Asymmetric Synthesis of Five-Membered Carbocycles

  摘要：

  Palladium-mediated hydrostannylation of alkynoyl compounds is combined with Stille-Scott cross-coupling (reductive-coupling) to give one-pot access to divinyl and aryl vinyl ketones, which undergo Nazarov cyclization to give cyclopentenones upon treatment with acid. This reaction sequence has been studied with a variety of different substitution patterns, including the use of oxazolidinone auxiliaries to achieve torquoselectivity in the Nazarov cyclization. Through a combination of good yields and moderate to good levels of stereochemical induction, this approach affords efficient, convergent, and asymmetric access to a variety of different cyclopentanoid systems.

  DOI：

  10.1021/jo100736p