3-methoxy-2-pyridyl 2,3,4-tri-O-benzoyl-6-O-tert-butyldiphenylsilyl-β-D-galactopyranoside | 347391-78-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-methoxy-2-pyridyl 2,3,4-tri-O-benzoyl-6-O-tert-butyldiphenylsilyl-β-D-galactopyranoside
• 英文别名: [(2R,3S,4S,5R,6S)-4,5-dibenzoyloxy-2-[[tert-butyl(diphenyl)silyl]oxymethyl]-6-(3-methoxypyridin-2-yl)oxyoxan-3-yl] benzoate
• CAS: 347391-78-0
• 化学式: C₄₉H₄₇NO₁₀Si
• 分子量: 837.998
• InChiKey: ARBLGSZQFXLWEG-QNHRZZPQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.45
• 重原子数：
  61
• 可旋转键数：
  18
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  129
• 氢给体数：
  0
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  3-benzyloxycarbonylamino-1-propyl 6-O-tert-butyldiphenylsilyl-2-deoxy-2-phthalimido-β-D-glucopyranoside 、 3-methoxy-2-pyridyl 2,3,4-tri-O-benzoyl-6-O-tert-butyldiphenylsilyl-β-D-galactopyranoside 在 copper(II) bis(trifluoromethanesulfonate) 作用下， 以 二氯甲烷 为溶剂， 反应 6.0h， 以64%的产率得到3-benzyloxycarbonylamino-1-propyl O-(2,3,4-tri-O-benzoyl-6-O-tert-butyldiphenylsilyl-β-D-galactopyranosyl)-(1-4)-6-O-tert-butyldiphenylsilyl-2-deoxy-2-phthalimido-β-D-glucopyranoside
  参考文献：
  名称：

  Practical syntheses of B disaccharide and linear B type 2 trisaccharide—non-primate epitope markers recognized by human anti-α-Gal antibodies causing hyperacute rejection of xenotransplants

  摘要：

  Synthetic protocols are presented for the elaboration of Gal alpha1 --> 3GalOR and Gal alpha1 --> 3Gal beta1 --> 4GlcNAcOR di- and trisaccharides that use a common Gal donor/acceptor unit, and are potentially adaptable to scale-up. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(01)00196-x
• 作为产物：
  描述：

  3-methoxy-2-pyridyl β-D-galactopyranoside 在 吡啶 、 咪唑 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 5.0h， 生成 3-methoxy-2-pyridyl 2,3,4-tri-O-benzoyl-6-O-tert-butyldiphenylsilyl-β-D-galactopyranoside
  参考文献：
  名称：

  Practical syntheses of B disaccharide and linear B type 2 trisaccharide—non-primate epitope markers recognized by human anti-α-Gal antibodies causing hyperacute rejection of xenotransplants

  摘要：

  Synthetic protocols are presented for the elaboration of Gal alpha1 --> 3GalOR and Gal alpha1 --> 3Gal beta1 --> 4GlcNAcOR di- and trisaccharides that use a common Gal donor/acceptor unit, and are potentially adaptable to scale-up. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(01)00196-x

文献信息

• Practical syntheses of B disaccharide and linear B type 2 trisaccharide—non-primate epitope markers recognized by human anti-α-Gal antibodies causing hyperacute rejection of xenotransplants
  作者：Stephen Hanessian、Oscar M Saavedra、Vincent Mascitti、Wolfgang Marterer、Reinhold Oehrlein、Ching-Pong Mak

  DOI：10.1016/s0040-4020(01)00196-x

  日期：2001.4

  Synthetic protocols are presented for the elaboration of Gal alpha1 --> 3GalOR and Gal alpha1 --> 3Gal beta1 --> 4GlcNAcOR di- and trisaccharides that use a common Gal donor/acceptor unit, and are potentially adaptable to scale-up. (C) 2001 Elsevier Science Ltd. All rights reserved.