2-O-benzoyl-β-D-glucopyranosyl-(1->3)-2-O-benzoyl-β-D-glucopyranosyl-(1->3)-2-O-benzoyl-β-D-glucopyranosyl-(1->3)-2-O-benzoyl-β-D-glucopyranosyl-(1->3)-2-O-benzoyl-β-D-glucopyranoside | 848224-20-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-O-benzoyl-β-D-glucopyranosyl-(1->3)-2-O-benzoyl-β-D-glucopyranosyl-(1->3)-2-O-benzoyl-β-D-glucopyranosyl-(1->3)-2-O-benzoyl-β-D-glucopyranosyl-(1->3)-2-O-benzoyl-β-D-glucopyranoside
• 英文别名: benzyl 2-O-benzoyl-beta-D-glucopyranosyl-(1->3)-2-O-benzoyl-beta-D-glucopyranosyl-(1->3)-2-O-benzoyl-beta-D-glucopyranosyl-(1->3)-2-O-benzoyl-beta-D-glucopyranosyl-(1->3)-2-O-benzoyl-beta-D-glucopyranoside；[(2S,3R,4S,5S,6R)-2-[(2S,3R,4S,5R,6R)-3-benzoyloxy-2-[(2S,3R,4S,5R,6R)-3-benzoyloxy-2-[(2S,3R,4S,5R,6R)-3-benzoyloxy-2-[(2R,3R,4S,5R,6R)-5-benzoyloxy-3-hydroxy-2-(hydroxymethyl)-6-phenylmethoxyoxan-4-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl] benzoate
• CAS: 848224-20-4
• 化学式: C₇₂H₇₈O₃₁
• 分子量: 1439.39
• InChiKey: DEWGYFMZYRHOAL-BMKYXERBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  103
• 可旋转键数：
  31
• 环数：
  11.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  446
• 氢给体数：
  11
• 氢受体数：
  31

反应信息

• 作为反应物：
  描述：

  2-O-benzoyl-β-D-glucopyranosyl-(1->3)-2-O-benzoyl-β-D-glucopyranosyl-(1->3)-2-O-benzoyl-β-D-glucopyranosyl-(1->3)-2-O-benzoyl-β-D-glucopyranosyl-(1->3)-2-O-benzoyl-β-D-glucopyranoside 在 sodium 作用下， 以 甲醇 为溶剂， 反应 7.0h， 生成 β-D-glucopyranosyl-(1->3)-β-D-glucopyranosyl-(1-3)-β-D-glucopyranosyl-(1->3)-β-D-glucopyranosyl-(1->3)-β-D-glucopyranoside
  参考文献：
  名称：

  US2005/65114

  摘要：

  公开号：
• 作为产物：
  描述：

  benzyl 2-O-benzoyl-4,6-O-benzylidene-β-D-glucopyranosyl-(1->3)-2-O-benzoyl-4,6-O-benzylidene-β-D-glucopyranosyl-(1->3)-2-O-benzoyl-4,6-O-benzylidene-β-D-glucopyranosyl-(1->3)-2-O-benzoyl-4,6-O-benzylidene-β-D-glucopyranosyl-(1->3)-2-O-benzoyl-4,6-O-benzylidene-β-D-glucopyranoside 在 对甲苯磺酸 作用下， 以 甲醇 、 水 、 丙酮 为溶剂， 反应 3.0h， 生成 2-O-benzoyl-β-D-glucopyranosyl-(1->3)-2-O-benzoyl-β-D-glucopyranosyl-(1->3)-2-O-benzoyl-β-D-glucopyranosyl-(1->3)-2-O-benzoyl-β-D-glucopyranosyl-(1->3)-2-O-benzoyl-β-D-glucopyranoside
  参考文献：
  名称：

  US2005/65114

  摘要：

  公开号：

文献信息

• Therapeutical treatment with oligo-beta- (1,3) -glucans, drugs used in said treatment
  申请人：Yvin Jean-Claude

  公开号：US20050065114A1

  公开（公告）日：2005-03-24

  A therapeutical method comprising administration of a composition comprising an amount of oligo-β-(1,3)-glucan and a pharmaceutically acceptable carrier, to a human being or to a warm-blood animal suffering from a disease selected from the group consisting in a tumor, a cancer, a viral disease, a bacterial disease, a fungal disease, a disease of the immune system, an auto-immune disease or a disease related to a deficiency of immunostimulation, wherein the amount of oligo-β-(1,3)-glucan is effective to treat the disease.

  一种治疗方法，包括向患有肿瘤、癌症、病毒性疾病、细菌性疾病、真菌性疾病、免疫系统疾病、自身免疫疾病或与免疫刺激不足有关的温血动物或人体内，注入含有寡聚β-(1,3)-葡聚糖和药学上可接受的载体的组合物，其中寡聚β-(1,3)-葡聚糖的剂量有效治疗该疾病。