(R)-trimethylsilylethyl [4-[3-(3,4-dimethoxyphenyl)-1-propanone]phenoxy]acetate | 215168-80-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: (R)-trimethylsilylethyl [4-[3-(3,4-dimethoxyphenyl)-1-propanone]phenoxy]acetate
• CAS: 215168-80-2
• 化学式: C₂₄H₃₄O₆Si
• 分子量: 446.616
• InChiKey: FODUEBJWTLFSTH-OAQYLSRUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.63
• 重原子数：
  31.0
• 可旋转键数：
  12.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  74.22
• 氢给体数：
  1.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  (R)-trimethylsilylethyl [4-[3-(3,4-dimethoxyphenyl)-1-propanone]phenoxy]acetate 在 4-二甲氨基吡啶 、 succinimidyl ester 、 四丁基氟化铵 、 三乙胺 、 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 、 二氯甲烷 、 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 7.0h， 生成 [(1R)-3-(3,4-dimethoxyphenyl)-1-[4-[2-[2-[[2-[4-[(1R)-3-(3,4-dimethoxyphenyl)-1-[(2S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carbonyl]oxypropyl]phenoxy]acetyl]amino]ethylamino]-2-oxoethoxy]phenyl]propyl] (2S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate
  参考文献：
  名称：

  Synthesis and activity of bivalent FKBP12 ligands for the regulated dimerization of proteins

  摘要：

  The total synthesis and in vitro activities of a series of chemical inducers of dimerization (CIDs) is described. The use of small-molecule CIDs to control the dimerization of engineered FKBP12-containing fusion proteins has been demonstrated to have broad utility in biological research as well as potential medical applications in gene and cell therapies. The facility and flexibility of preparation make this new class of wholly synthetic compounds exceptionally versatile tools for the study of intracellular signaling events mediated by protein-protein interactions or protein localization. While some congeners possess potency comparable to or better than the first generation natural product-derived CID, FK1012, structure-activity relationships are complex and underscore the need for application-specific compound optimizations. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(98)00125-4
• 作为产物：
  描述：

  {4-[3-(3,4-Dimethoxy-phenyl)-propionyl]-phenoxy}-acetic acid 2-trimethylsilanyl-ethyl ester 在 (+)-二异松蒎基氯硼烷 作用下， 以 四氢呋喃 为溶剂， 以91%的产率得到(R)-trimethylsilylethyl [4-[3-(3,4-dimethoxyphenyl)-1-propanone]phenoxy]acetate
  参考文献：
  名称：

  Synthesis and activity of bivalent FKBP12 ligands for the regulated dimerization of proteins

  摘要：

  The total synthesis and in vitro activities of a series of chemical inducers of dimerization (CIDs) is described. The use of small-molecule CIDs to control the dimerization of engineered FKBP12-containing fusion proteins has been demonstrated to have broad utility in biological research as well as potential medical applications in gene and cell therapies. The facility and flexibility of preparation make this new class of wholly synthetic compounds exceptionally versatile tools for the study of intracellular signaling events mediated by protein-protein interactions or protein localization. While some congeners possess potency comparable to or better than the first generation natural product-derived CID, FK1012, structure-activity relationships are complex and underscore the need for application-specific compound optimizations. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(98)00125-4