Succinic acid mono-((R)-2,3-bis-octadecyloxy-propyl) ester | 1019000-69-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Succinic acid mono-((R)-2,3-bis-octadecyloxy-propyl) ester
• 英文别名: 4-[(2R)-2,3-dioctadecoxypropoxy]-4-oxobutanoic acid
• CAS: 1019000-69-1
• 化学式: C₄₃H₈₄O₆
• 分子量: 697.136
• InChiKey: PNUXIGXXVIHLDO-VQJSHJPSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  17
• 重原子数：
  49
• 可旋转键数：
  43
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  82.1
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  Succinic acid mono-((R)-2,3-bis-octadecyloxy-propyl) ester 在 三乙胺 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 、 二甲基亚砜 、 N,N-二甲基甲酰胺 为溶剂， 反应 6.0h， 生成
  参考文献：
  名称：

  Synthesis of Neoglycolipids Containing Oligosaccharides Based on 3,6-Branched-α-D-Mannopyranosides as the Carbohydrate Moieties

  摘要：

  Several oligosaccharides containing 3,6-branched-alpha-D-mannopyranosides were obtained by selective glycosylation of 5-azido-3-oxapentyl alpha-D-mannopyranoside with acetobromosugars. After deacetylation and reduction of the spacer azido group, the oligosaccharides were coupled with the activated hemisuccinate derivatives of cholesterol and 1,2-di-O-alkylglycerol. The neoglycolipids so obtained were characterized by NMR spectroscopy and will be used as liposome coating molecules for targeting entrapped antigens.

  DOI：

  10.1080/07328309808007460
• 作为产物：
  描述：

  (R)-((2,3-bis(octadecyloxy)propoxy)methyl)benzene 在 palladium on activated charcoal 4-二甲氨基吡啶 、 氢气 作用下， 以 吡啶 、 氯仿 、 乙酸乙酯 为溶剂， 反应 36.0h， 生成 Succinic acid mono-((R)-2,3-bis-octadecyloxy-propyl) ester
  参考文献：
  名称：

  Synthesis of Neoglycolipids Containing Oligosaccharides Based on 3,6-Branched-α-D-Mannopyranosides as the Carbohydrate Moieties

  摘要：

  Several oligosaccharides containing 3,6-branched-alpha-D-mannopyranosides were obtained by selective glycosylation of 5-azido-3-oxapentyl alpha-D-mannopyranoside with acetobromosugars. After deacetylation and reduction of the spacer azido group, the oligosaccharides were coupled with the activated hemisuccinate derivatives of cholesterol and 1,2-di-O-alkylglycerol. The neoglycolipids so obtained were characterized by NMR spectroscopy and will be used as liposome coating molecules for targeting entrapped antigens.

  DOI：

  10.1080/07328309808007460

文献信息

• WO2008/42973
  申请人：——

  公开号：——

  公开（公告）日：——
• Lipid containing formulations
  申请人：Arbutus Biopharma Corporation

  公开号：EP2695608B1

  公开（公告）日：2016-11-23