| 1255515-97-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1255515-97-9
• 化学式: C₃₇H₅₆N₈O₁₅P₂Si₂
• 分子量: 971.015
• InChiKey: DQLUURKKERJATR-QGQJFHJHSA-N

反应信息

• 作为反应物：
  描述：

  在 氨 、 水 作用下， 以 甲醇 为溶剂， 反应 12.0h， 生成
  参考文献：
  名称：

  Synthesis of cyclic di-nucleotidic acids as potential inhibitors targeting diguanylate cyclase

  摘要：

  Five analogs of cyclic di-nucleotidic acid including c-di-GMP were synthesized and evaluated for their biological activities on Slr1143, a diguanylate cyclase of Synechocystis sp. Slr1143 was overexpressed from the recombinant plasmid which contained the gene of interest and subsequently purified by affinity chromatography. A new HPLC method capable of separating the compound and product peaks with good resolution was optimized and applied to the analysis of the compounds. Results obtained show that cyclic di-inosinylic acid 1b demonstrates a stronger inhibition on Slr1143 than c-di-GMP and is a potential inhibitor for biofilm formation. (c) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.07.068
• 作为产物：
  描述：

  在 N-甲基咪唑 、 2,4,6-三异丙基苯磺酰氯 作用下， 以 四氢呋喃 为溶剂， 生成
  参考文献：
  名称：

  Synthesis of cyclic di-nucleotidic acids as potential inhibitors targeting diguanylate cyclase

  摘要：

  Five analogs of cyclic di-nucleotidic acid including c-di-GMP were synthesized and evaluated for their biological activities on Slr1143, a diguanylate cyclase of Synechocystis sp. Slr1143 was overexpressed from the recombinant plasmid which contained the gene of interest and subsequently purified by affinity chromatography. A new HPLC method capable of separating the compound and product peaks with good resolution was optimized and applied to the analysis of the compounds. Results obtained show that cyclic di-inosinylic acid 1b demonstrates a stronger inhibition on Slr1143 than c-di-GMP and is a potential inhibitor for biofilm formation. (c) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.07.068