(S)-2-(1,2,3,4-Tetrahydro-quinolin-2-yl)-ethanol | 502846-71-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (S)-2-(1,2,3,4-Tetrahydro-quinolin-2-yl)-ethanol
• 英文别名: 2-[(2S)-1,2,3,4-tetrahydroquinolin-2-yl]ethanol
• CAS: 502846-71-1
• 化学式: C₁₁H₁₅NO
• 分子量: 177.246
• InChiKey: XYKHXADEXVAGSF-JTQLQIEISA-N

物化性质

• 沸点：
  339.1±11.0 °C(Predicted)
• 密度：
  1.058±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (S)-2-(1,2,3,4-Tetrahydro-quinolin-2-yl)-ethanol 在 咪唑 、 碘 、 三苯基膦 作用下， 以91%的产率得到(S)-2-(2-Iodo-ethyl)-1,2,3,4-tetrahydro-quinoline
  参考文献：
  名称：

  Regio- and stereoselective α-allylation of quinolines activated by chloroformate and triflate ion by means of chiral allylsilane: a synthesis of chiral 2-substituted 1,2-dihydroquinolines

  摘要：

  Addition reactions of a chiral allylsilane to a variety of quinolines activated by phenyl chloroformate and triflate ion proceed with high regio- and stereoselectivities to afford various chiral 2-allylated 1,2-dihydroqLlinolines in good yields. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)02201-3
• 作为产物：
  描述：

  methyl (S)-1,2,3,4-tetrahydroquinoline-2-acetate 在 lithium aluminium tetrahydride 作用下， 以94%的产率得到(S)-2-(1,2,3,4-Tetrahydro-quinolin-2-yl)-ethanol
  参考文献：
  名称：

  Regio- and stereoselective α-allylation of quinolines activated by chloroformate and triflate ion by means of chiral allylsilane: a synthesis of chiral 2-substituted 1,2-dihydroquinolines

  摘要：

  Addition reactions of a chiral allylsilane to a variety of quinolines activated by phenyl chloroformate and triflate ion proceed with high regio- and stereoselectivities to afford various chiral 2-allylated 1,2-dihydroqLlinolines in good yields. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)02201-3