1-(2-methacryloyloxy)ethyl-3-ethylimidazolium chloride | 959927-19-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-(2-methacryloyloxy)ethyl-3-ethylimidazolium chloride
• 英文别名: 2-(3-Ethylimidazol-1-ium-1-yl)ethyl 2-methylprop-2-enoate;chloride
• CAS: 959927-19-6
• 化学式: C₁₁H₁₇N₂O₂*Cl
• 分子量: 244.721
• InChiKey: DSVVMAUBJCCCEA-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -2.08
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  35.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-乙基咪唑 、 2-氯乙基甲基丙烯酸盐 反应 48.0h， 以95%的产率得到1-(2-methacryloyloxy)ethyl-3-ethylimidazolium chloride
  参考文献：
  名称：

  有效添加有机氯化物盐对氟代醇中原子转移自由基聚合的影响

  摘要：

  在有机氯化物盐，咪唑氯化物存在下，使用烷基溴引发剂在甲基丙烯酸甲酯（MMA）的原子转移自由基聚合（ATRP）中，在333 K下于2,2,2-三氟乙醇（TFE）中进行。足够数量的氯化物盐以受控方式进行，以生产分子量分布窄的聚合物（M w / M n<1.2）。使用烷基溴和咪唑氯化物的模型反应表明，在TFE中的ATRP过程中发生了卤素交换反应，从而从烷基溴形成了一个氯化物末端的繁殖物。但是，使用烷基氯引发剂和CuCl催化剂的TFE中MMA的ATRP引发效率低，并且失去了对聚合的控制。烷基溴化物引发剂，CuBr和足够量的有机氯化物盐的组合非常有效地改善了质子溶剂（尤其是氟代醇）中对ATRP的控制。合成了具有咪唑鎓氯化物部分的甲基丙烯酸酯单体，并通过ATRP聚合而未添加氯化物盐，以制备分子量控制得很好且多分散性窄的聚合物。

  DOI：

  10.1021/ma401857w

文献信息

• Volume response sensors having analyte controlled reversible crosslinking
  申请人：The Board of Trustees of the University of Illinois

  公开号：US10088476B2

  公开（公告）日：2018-10-02

  The invention relates to hydrogel and organogel sensors as well as their application to continuous analyte monitoring. The sensor can include a hydrogel or organogel matrix. Standard and inverse designed are provided. In one embodiment, the matrix can include a molecular recognition agent for an analyte (e.g., a glucose analyte), and a volume resetting agent that reversibly binds with the molecular recognition agent. Reversible crosslinks between the molecular recognition agent and volume resetting agent can change the volume of the matrix upon interacting with the analyte via a competitive binding process. In various embodiments, the invention provides a hydrogel-based glucose sensor and sensors for continuous glucose monitoring. The glucose sensor can be based on a glucose-responsive hydrogel with a volume linearly correlated with glucose concentrations, such as about 0.05-50 mM, under physiological conditions. The invention thus provides a blood glucose monitor suitable for use in clinical settings.

  本发明涉及水凝胶和有机凝胶传感器及其在连续分析监测中的应用。传感器可包括水凝胶或有机凝胶基质。提供了标准设计和反向设计。在一个实施方案中，基质可包括分析物（如葡萄糖分析物）的分子识别剂和与分子识别剂可逆结合的体积重置剂。分子识别剂和体积复位剂之间的可逆交联可通过竞争性结合过程在与分析物相互作用时改变基质的体积。在各种实施方案中，本发明提供了一种基于水凝胶的葡萄糖传感器和用于连续葡萄糖监测的传感器。葡萄糖传感器可以基于葡萄糖响应水凝胶，在生理条件下，水凝胶的体积与葡萄糖浓度（如约 0.05-50 mM）呈线性相关。因此，本发明提供了一种适用于临床环境的血糖监测仪。
• VOLUME RESPONSE SENSORS HAVING ANALYTE CONTROLLED REVERSIBLE CROSSLINKING
  申请人：CANO Gerry G.

  公开号：US20160252505A1

  公开（公告）日：2016-09-01

  The invention relates to hydrogel and organogel sensors as well as their application to continuous analyte monitoring. The sensor can include a hydrogel or organogel matrix. Standard and inverse designed are provided. In one embodiment, the matrix can include a molecular recognition agent for an analyte (e.g., a glucose analyte), and a volume resetting agent that reversibly binds with the molecular recognition agent. Reversible crosslinks between the molecular recognition agent and volume resetting agent can change the volume of the matrix upon interacting with the analyte via a competitive binding process. In various embodiments, the invention provides a hydrogel-based glucose sensor and sensors for continuous glucose monitoring. The glucose sensor can be based on a glucose-responsive hydrogel with a volume linearly correlated with glucose concentrations, such as about 0.05-50 mM, under physiological conditions. The invention thus provides a blood glucose monitor suitable for use in clinical settings.
• SURFACES COMPRISING ATTACHED QUORUM SENSING MODULATORS
  申请人：The Trustees of Princeton University

  公开号：US20180125066A1

  公开（公告）日：2018-05-10

  The invention relates to compositions comprising QS modulating molecules attached to a surface via a linker. This QS modulator attached surface can then be used to modulate QS, biofilm production, biofilm streamer production and/or virulence factor production. The length of the linker that attaches the QS modulating molecule to the surface as well as the surface coverage density are features that impact QS modulation on surfaces. These QS modulator attached surfaces can be used to treat areas known to contain human pathogens notorious for causing hospital-acquired infections as well as fatal infections that occur outside of health care settings. Other surfaces that can be coated according to embodiments of the invention include abiotic materials, such as intravenous catheters, implants, medical devices, and cooling towers. Preferred microorganisms that can be treated with the compositions of the invention include, but are not limited to S. aureus and/or P. aeruginosa . The QS modulator attached surface also demonstrates exceptional stability.
• DIAGNOSTIC AND THERAPEUTIC QUORUM-SENSING-MANIPULATION MOLECULES THAT ARE TRACKABLE FOR HEALTH-CARE AND INDUSTRIAL SYSTEMS.
  申请人：The Trustees of Princeton University

  公开号：US20180346525A1

  公开（公告）日：2018-12-06

  According to present invention embodiments, a trackable moiety can be attached to a quorum sensing (QS) molecule to form a QS modulating conjugate. QS modulating conjugates retain their activity for QS manipulation and are able to be detected by imaging techniques. The QS portion of the QS modulating conjugate can play a role in affecting bacterial behaviors, such as, inhibition of biofilms or disruption of toxin production, while the trackable moiety of the QS modulating conjugate enables monitoring, visualization in real time of its binding to the receptor on the bacterial surface, and the location of the bacterium itself, for example, in a biofilm and/or at an infection site. Since binding of the QS modulating conjugate to its cognate receptor is specific, the QS modulating conjugate can be used for diagnostic applications by enabling pinpointing of specific bacteria at infection sites.
• [EN] SURFACES COMPRISING ATTACHED QUORUM SENSING MODULATORS<br/>[FR] SURFACES COMPRENANT DES MODULATEURS DE DÉTECTION DU QUORUM FIXÉS
  申请人：UNIV PRINCETON

  公开号：WO2016176146A1

  公开（公告）日：2016-11-03

  The invention relates to compositions comprising QS modulating molecules attached to a surface via a linker. This QS modulator attached surface can then be used to modulate QS, biofilm production, biofilm streamer production and/or virulence factor production. These QS modulator attached surfaces can be used to treat areas known to contain human pathogens notorious for causing hospital-acquired infections as well as fatal infections that occur outside of health care settings. Other surfaces that can be coated according to embodiments of the invention include abiotic materials, such as intravenous catheters, implants, medical devices, and cooling towers. Preferred microorganisms that can be treated with the compositions of the invention include, but are not limited to S. aureus and/or P. aeruginosa.