| 162737-83-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 162737-83-9
• 化学式: C₄₀H₆₉N₃O₁₂
• 分子量: 784.001
• InChiKey: POVBDAQAQDAYFF-JILIYYCLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.96
• 重原子数：
  55.0
• 可旋转键数：
  20.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  186.74
• 氢给体数：
  5.0
• 氢受体数：
  14.0

反应信息

• 作为反应物：
  描述：

  在 palladium on activated charcoal 氢气 、 sodium cyanoborohydride 作用下， 生成
  参考文献：
  名称：

  Chimeric azalides with simplified western portions

  摘要：

  A series of chimeric azalides which are homologous to the azalide antibiotics 2 and 4 in their eastern halves but which have functionally simplified western halves have been semisynthesized from erythromycin A. These chimeric azalides include both macrolactones and macrolactams and vary in ring size from 13 to 16 members. The synthesis, which establishes the ring via a macrolactonization or macrolactamization reaction, requires no protecting groups on the eastern half of the molecule, including the sugars.

  DOI：

  10.1016/s0040-4039(00)73915-3
• 作为产物：
  描述：

  3-(苄氧羰基氨基)-1-丙醇 在 草酰氯 、 sodium cyanoborohydride 、 二甲基亚砜 、 三乙胺 作用下， 生成
  参考文献：
  名称：

  Chimeric azalides with simplified western portions

  摘要：

  A series of chimeric azalides which are homologous to the azalide antibiotics 2 and 4 in their eastern halves but which have functionally simplified western halves have been semisynthesized from erythromycin A. These chimeric azalides include both macrolactones and macrolactams and vary in ring size from 13 to 16 members. The synthesis, which establishes the ring via a macrolactonization or macrolactamization reaction, requires no protecting groups on the eastern half of the molecule, including the sugars.

  DOI：

  10.1016/s0040-4039(00)73915-3