2,2,4,4-tetramethyl-3-(4-acetyl)benzylidene-1,5-dioxa-2,4-disilacycloheptane | 1177254-30-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,2,4,4-tetramethyl-3-(4-acetyl)benzylidene-1,5-dioxa-2,4-disilacycloheptane
• 英文别名: 1-[4-[(2,2,4,4-Tetramethyl-1,5,2,4-dioxadisilepan-3-ylidene)methyl]phenyl]ethanone；1-[4-[(2,2,4,4-tetramethyl-1,5,2,4-dioxadisilepan-3-ylidene)methyl]phenyl]ethanone
• CAS: 1177254-30-6
• 化学式: C₁₆H₂₄O₃Si₂
• 分子量: 320.536
• InChiKey: NFEIFVBZHQBHCI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.81
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,2,4,4-tetramethyl-3-(4-acetyl)benzylidene-1,5-dioxa-2,4-disilacycloheptane 、 (E)-1-(2-iodovinyl)-4-methylbenzene 在 bis(η3-allyl-μ-chloropalladium(II)) 、 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以80%的产率得到(E,E)-1-(4-acetylphenyl)-4-(4-methylphenyl)buta-1,3-diene
  参考文献：
  名称：

  Cyclic 1,1-bis(silyl)alkenes—new building blocks for the stereoselective synthesis of unsymmetrical (E)-stilbenes and (E,E)-1,4-diarylbuta-1,3-dienes

  摘要：

  A new efficient synthetic protocol for the highly stereoselective synthesis Of Unsymmetrical (or symmetrical) (E)-stilbenes and (E,E)-1,4-diarylbuta-1,3-dienes based on sequential palladium-catalyzed Heck arylation-Hiyama cross-coupling reactions using cyclic gem-bis(silyl)ethene as alkenyl building block is reported. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.01.113
• 作为产物：
  描述：

  4-碘代苯乙酮 、 2,2,4,4-tetramethyl-1,5-dioxa-3-methylene-2,4-disilacycloheptane 在 palladium diacetate 、 silver nitrate 、 三乙胺 、 三苯基膦 作用下， 以 乙腈 为溶剂， 反应 1.0h， 以72%的产率得到2,2,4,4-tetramethyl-3-(4-acetyl)benzylidene-1,5-dioxa-2,4-disilacycloheptane
  参考文献：
  名称：

  Cyclic 1,1-bis(silyl)alkenes—new building blocks for the stereoselective synthesis of unsymmetrical (E)-stilbenes and (E,E)-1,4-diarylbuta-1,3-dienes

  摘要：

  A new efficient synthetic protocol for the highly stereoselective synthesis Of Unsymmetrical (or symmetrical) (E)-stilbenes and (E,E)-1,4-diarylbuta-1,3-dienes based on sequential palladium-catalyzed Heck arylation-Hiyama cross-coupling reactions using cyclic gem-bis(silyl)ethene as alkenyl building block is reported. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.01.113

文献信息

• Cyclic 1,1-bis(silyl)alkenes—new building blocks for the stereoselective synthesis of unsymmetrical (E)-stilbenes and (E,E)-1,4-diarylbuta-1,3-dienes
  作者：Piotr Pawluć、Grzegorz Hreczycho、Andrzej Suchecki、Maciej Kubicki、Bogdan Marciniec

  DOI：10.1016/j.tet.2009.01.113

  日期：2009.7

  A new efficient synthetic protocol for the highly stereoselective synthesis Of Unsymmetrical (or symmetrical) (E)-stilbenes and (E,E)-1,4-diarylbuta-1,3-dienes based on sequential palladium-catalyzed Heck arylation-Hiyama cross-coupling reactions using cyclic gem-bis(silyl)ethene as alkenyl building block is reported. (C) 2009 Elsevier Ltd. All rights reserved.