5-((1,4,8,12-tetraazacyclopentadecan-8-yl)methyl)quinolin-8-ol | 918907-60-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 5-((1,4,8,12-tetraazacyclopentadecan-8-yl)methyl)quinolin-8-ol
• 英文别名: 5-(1,4,8,12-tetrazacyclopentadec-8-ylmethyl)quinolin-8-ol
• CAS: 918907-60-5
• 化学式: C₂₁H₃₃N₅O
• 分子量: 371.526
• InChiKey: QQAISVITWCCCIC-UHFFFAOYSA-N

物化性质

• 沸点：
  574.6±50.0 °C(Predicted)
• 密度：
  1.063±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  27
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  72.4
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  tri(tert-butyl) 12-((8-hydroxyquinolin-5-yl)methyl)-1,4,8,12-tetraazacyclopentadecane-1,4,8-tricarboxylate 在 盐酸 作用下， 以 乙醚 为溶剂， 以100%的产率得到5-((1,4,8,12-tetraazacyclopentadecan-8-yl)methyl)quinolin-8-ol
  参考文献：
  名称：

  Synthesis and anti-HIV properties of new hydroxyquinoline–polyamine conjugates on cells infected by HIV-1 LAV and HIV-1 BaL viral strains

  摘要：

  To find new derivatives that block different virus strains entry in cells bearing specific surface receptors represent an interesting challenge for medicinal chemists. Here, we report the synthesis and the anti-HIV properties of a new series of analogues based on the introduction of quinoline moiety on various polyamine backbones, including polyazamacrocycles. Three compounds 7, 8, and 10 of this series were found active on PBMCs cells infected by HIV-1 LAV or by HIV-1 BaL, in contrast the well-known reference compound 1a (AMD 3100) was found only active on HIV-1 LAV strain.

  DOI：

  10.1016/j.bmcl.2006.08.114

文献信息

• [EN] PPAR AGONIST COMPOSITIONS AND METHODS OF USE<br/>[FR] COMPOSITIONS AGONISTES DE PPAR ET PROCÉDÉS D'UTILISATION
  申请人：BIOPHARMED

  公开号：WO2010073235A1

  公开（公告）日：2010-07-01

  Method for treating or preventing a PPAR-responsive condition in a subject, comprising administering to the subject a PPAR agonist that comprises a 8-hydroxyquinoline-methylene-N- group in an amount effective to activate a PPAR polypeptide.

  治疗或预防主体的PPAR响应性疾病的方法，包括向主体给予一种PPAR激动剂，该激动剂包括一种8-羟基喹啉-亚甲基-N-基团，其有效剂量能够激活PPAR多肽。
• PPAR AGONIST COMPOSITIONS AND METHODS OF USE
  申请人：Kraus Jean-Louis

  公开号：US20110251238A1

  公开（公告）日：2011-10-13

  Method for treating or preventing a PPAR-responsive condition in a subject, comprising administering to the subject a PPAR agonist that comprises a 8-hydroxyquinoline-methylene-N- group in an amount effective to activate a PPAR polypeptide.

  治疗或预防受体PPAR反应性疾病的方法，包括向受体施用含有8-羟基喹啉-亚甲基-N-基团的PPAR激动剂，以有效激活PPAR多肽。
• DÉRIVÉS DE LA CLASSE DES HYDROXYQUINOLÉINES AMINÉES POUR LE TRAITEMENT DE CANCERS.
  申请人：Biopharmed Société à Responsabilité Limitée

  公开号：EP2139860A2

  公开（公告）日：2010-01-06
• Derivatives of the Aminated Hydroxyquinoline Class For Treating Cancers
  申请人：Kraus Jean-Louis

  公开号：US20100120856A1

  公开（公告）日：2010-05-13

  The invention relates to compounds of the animated hydroxyquinoline type capable of preventing the migration of metastases or tumoral cells. Such compounds are useful for treating cancers.
• US8324243B2
  申请人：——

  公开号：US8324243B2

  公开（公告）日：2012-12-04