4-[2-(5-deoxy-5-phthaloylamino-β-D-ribofuranos-1-yl)ethyl]-1-[2-(trimethylsilyl)ethoxymethyl]imidazole | 1267845-66-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-[2-(5-deoxy-5-phthaloylamino-β-D-ribofuranos-1-yl)ethyl]-1-[2-(trimethylsilyl)ethoxymethyl]imidazole
• CAS: 1267845-66-8
• 化学式: C₂₄H₃₃N₃O₆Si
• 分子量: 487.628
• InChiKey: FJZZQEBXYGPFPU-LNRXMEIDSA-N

反应信息

• 作为产物：
  描述：

  邻苯二甲酸亚胺 、 4-[2-(2,3,5-tri-O-benzyl-β-D-ribofuranos-1-yl)vinyl]-1H-imidazole 、 2-(三甲基硅烷基)乙氧甲基氯 在 sodium hydride 作用下， 以 四氢呋喃 、 mineral oil 为溶剂， 反应 2.5h， 生成 5-[2-(5-deoxy-5-phthaloylamino-β-D-ribofuranos-1-yl)ethyl]-1-[2-(trimethylsilyl)ethoxymethyl]imidazole 、 4-[2-(5-deoxy-5-phthaloylamino-β-D-ribofuranos-1-yl)ethyl]-1-[2-(trimethylsilyl)ethoxymethyl]imidazole
  参考文献：
  名称：

  Synthesis of Two Estradiol-Imidazole C-Ribonucleoside Hybrid Compounds Exhibiting Inhibitory Effects against Type 1 17β-Hydroxysteroid Dehydrogenase

  摘要：

  Novel estradiol-imidazole C-nucleoside hybrid compounds 4a and 4b, which have C4-linked C-0- and C-2-imidazole ribonucleosides as adenosine mimics and amide bond linkers, were designed and synthesized based on EM-1745, an inhibitor of type 1 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD1). Compounds 4a and 4b were also tested as enzyme inhibitors.

  DOI：

  10.3987/com-10-12069