4-乙酰基苯磺酸 | 34074-93-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 4-乙酰基苯磺酸
• 英文名称: p-Acetylbenzolsulfonsaeure
• 英文别名: 4-acetylbenzenesulfonic Acid
• CAS: 34074-93-6
• 化学式: C₈H₈O₄S
• mdl: MFCD06680100
• 分子量: 200.215
• InChiKey: ACPXHHDRVABPNY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.125
• 拓扑面积：
  79.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4'-巯基苯乙酮 在 硝酸 作用下， 生成 4-乙酰基苯磺酸
  参考文献：
  名称：

  Riess; Frankfurter, Monatshefte fur Chemie, 1928, vol. 50, p. 71

  摘要：

  DOI：

文献信息

• NIR TO SWIR FLUORESCENT COMPOUNDS FOR IMAGING AND DETECTION
  申请人：PERKINELMER HEALTH SCIENCES, INC.

  公开号：US20190100654A1

  公开（公告）日：2019-04-04

  This disclosure provides a family of compounds that absorb and fluoresce in the short wave infrared region (SWIR, optionally 1000 nm to 1300 nm), including hydrophilic compounds that exhibit absorption and emission spectral profiles in aqueous solutions substantially similar to those observed in organic solvents such as methanol or DMSO. The compounds can be chemically linked to biomolecules including proteins, nucleic acids, and therapeutic small molecules. The compounds are useful for imaging in a variety of medical, biological and diagnostic applications, including SWIR in vivo imaging of regions of interest within a mammal.

  这份披露提供了一类在短波红外区域（SWIR，可选1000纳米至1300纳米）吸收和发射光的化合物家族，包括在水溶液中表现出吸收和发射光谱特性与甲醇或DMSO等有机溶剂中观察到的基本相似的亲水性化合物。这些化合物可以与蛋白质、核酸和治疗性小分子等生物分子化学连接。这些化合物可用于在各种医学、生物学和诊断应用中进行成像，包括对哺乳动物体内感兴趣区域进行SWIR成像。
• [EN] PYRROLE AND PYRAZOLE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS<br/>[FR] COMPOSES DE PYRROLE ET PYRAZOLE PRESENTANT UN EFFET POTENTIATEUR SUR LES RECEPTEURS DU GLUTAMATE
  申请人：LILLY CO ELI

  公开号：WO2005040110A1

  公开（公告）日：2005-05-06

  The present invention relates to pyrrole and pyrazole compounds of formula (I) and their pharmaceutically acceptable salts, and further relates to their use in treating schizophrenia, cognitive deficits associated with schizophrenia, Alzheimer's disease, dementia of the Alzheimer's type, mild cognitive impairment, or depression. The compounds act as potentiators on glutamate receptors, in particular AMPA and the GluR family.

  本发明涉及式(I)的吡咯和吡唑化合物及其药用可接受的盐，并且进一步涉及它们在治疗精神分裂症、与精神分裂症相关的认知缺陷、阿尔茨海默病、阿尔茨海默型痴呆、轻度认知障碍或抑郁症方面的应用。这些化合物作为谷氨酸受体的增强剂，特别是AMPA和GluR家族。
• Colorant compounds
  申请人：Banning H. Jeffrey

  公开号：US20060020141A1

  公开（公告）日：2006-01-26

  Compounds of the formula wherein M is either (1) a metal ion having a positive charge of +y wherein y is an integer which is at least 2, said metal ion being capable of forming a compound with at least two chromogen moieties, or (2) a metal-containing moiety capable of forming a compound with at least two chromogen moieties, z is an integer representing the number of chromogen moieties associated with the metal and is at least 2, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , a, b, c, d, Y, and z are as defined herein, Q − is a COO − group or a SO 3 — group, A is an organic anion, and CA is either a hydrogen atom or a cation associated with all but one of the Q − groups.

  式中的化合物，其中M是一个带有正电荷+y的金属离子，其中y是至少为2的整数，该金属离子能够与至少两个色团基团形成化合物，或者M是一个含金属基团的基团，能够与至少两个色团基团形成化合物，z是表示与金属相关的色团基团数量的整数，至少为2，R1、R2、R3、R4、R5、R6、R7、a、b、c、d、Y和z的定义如上所述，Q-是一个COO-基团或SO3-基团，A是一个有机阴离子，CA是一个氢原子或与除一个Q-基团之外的所有Q-基团相关联的阳离子。
• Ligand Tuning in Pyridine-Alkoxide Ligated Cp*Ir^III Oxidation Catalysts
  作者：Emma V. Sackville、Gabriele Kociok-Köhn、Ulrich Hintermair

  DOI：10.1021/acs.organomet.7b00492

  日期：2017.9.25

  these precursors to catalytic C–H oxidation of ethyl benzenesulfonate with aqueous sodium periodate showed that the ligand substitution pattern, solution pH, and solvent all have pronounced influences on initial rates and final conversion values. Correlation with O2 evolution profiles during C–H oxidation catalysis showed these competing reactions to occur sequentially, and demonstrates how it is possible

  吡啶醇盐连接的六种新型衍生物Cp * Ir III配合物（均质水和CH-H氧化催化剂的有效前体）已经合成，表征并通过光谱和动力学分析了配体效应。发现醇盐和吡啶取代基的变化会影响它们的溶液形态，活化行为和氧化动力学。这些前体在高碘酸钠水溶液催化CH-H氧化苯磺酸乙酯中的应用表明，配体的取代方式，溶液的pH值和溶剂都对初始速率和最终转化率有显着影响。与O 2相关 在C–H氧化催化过程中的演化曲线表明，这些竞争反应是相继发生的，并证明了如何通过N ^ O配体结构调节活性物种的活性和选择性。
• METAL OXIDE-ORGANIC HYBRID MATERIALS FOR HETEROGENEOUS CATALYSIS AND METHODS OF MAKING AND USING THEREOF
  申请人：Yale University

  公开号：US20160152648A1

  公开（公告）日：2016-06-02

  Catalysts prepared from abundant, cost effective metals, such as cobalt, nickel, chromium, manganese, iron, and copper, and containing one or more neutrally charged ligands (e.g., monodentate, bidentate, and/or polydentate ligands) and methods of making and using thereof are described herein. Exemplary ligands include, but are not limited to, phosphine ligands, nitrogen-based ligands, sulfur-based ligands, and/or arsenic-based ligands. In some embodiments, the catalyst is a cobalt-based catalyst or a nickel-based catalyst. The catalysts described herein are stable and active at neutral pH and in a wide range of buffers that are both weak and strong proton acceptors. While its activity is slightly lower than state of the art cobalt-based water oxidation catalysts under some conditions, it is capable of sustaining electrolysis at high applied potentials without a significant degradation in catalytic current. This enhanced robustness gives it an advantage in industrial and large-scale water electrolysis schemes.

  本文描述了由丰富、成本效益的金属（如钴、镍、铬、锰、铁和铜）制备的催化剂，其中包含一个或多个中性配体（例如，单齿、双齿和/或多齿配体）及其制备和使用方法。示例配体包括，但不限于，膦配体、氮基配体、硫基配体和/或砷基配体。在某些实施例中，催化剂是基于钴或基于镍的催化剂。本文描述的催化剂在中性pH值下以及在既是弱质子受体又是强质子受体的各种缓冲液中都是稳定和活性的。在某些条件下，虽然其活性略低于现有技术水氧化钴基催化剂，但它能够在高施加电位下维持电解而不会出现催化电流的显着降解。这种增强的稳健性使其在工业和大规模水电解方案中具有优势。