butyl-9-methoxy-5-(4-(trifluoromethyl)phenyl)-3,4-dihydrobenzo[h][1,6]naphthyridin-2(1H)-one | 1208005-44-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: butyl-9-methoxy-5-(4-(trifluoromethyl)phenyl)-3,4-dihydrobenzo[h][1,6]naphthyridin-2(1H)-one
• CAS: 1208005-44-0
• 化学式: C₂₄H₂₃F₃N₂O₂
• 分子量: 428.454
• InChiKey: MXNOCNWRBWYURN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.01
• 重原子数：
  31.0
• 可旋转键数：
  5.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  42.43
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  (4aRS,5SR,10bRS)-1-butyl-9-methoxy-5-(4-(trifluoromethyl)phenyl)-1,4,4a,5,6,10b-hexahydrobenzo[h][1,6]naphthyridin-2(3H)-one 在 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 氯仿 为溶剂， 反应 24.0h， 以84%的产率得到butyl-9-methoxy-5-(4-(trifluoromethyl)phenyl)-3,4-dihydrobenzo[h][1,6]naphthyridin-2(1H)-one
  参考文献：
  名称：

  Unsaturated Lactams: New Inputs for Povarov-Type Multicomponent Reactions

  摘要：

  Unsaturated lactams with endo- or exocyclic C-C double bonds constitute a set of reactive inputs that serve as the electron-rich olefin component in Povarov reactions. These substrates afford the multicomponent adducts in convenient yields and offer a wide range of structural diversity. Postcondensation transformations allow direct access to a variety of lactam-fused and amide-substituted quinoline derivatives.

  DOI：

  10.1021/ol902913j

文献信息

• Multicomponent reaction access to complex quinolines via oxidation of the Povarov adducts
  作者：Esther Vicente-García、Rosario Ramón、Sara Preciado、Rodolfo Lavilla

  DOI：10.3762/bjoc.7.110

  日期：——

  The tetrahydroquinolines obtained through the Povarov multicomponent reaction have been oxidized to the corresponding quinoline, giving access to a single product through a two-step sequence. Several oxidizing agents were studied and manganese dioxide proved to be the reagent of choice, affording higher yields, cleaner reactions and practical protocols.

  通过波瓦洛夫多组分反应获得的四氢喹啉被氧化成相应的喹啉，通过两步顺序获得单一产物。对几种氧化剂进行了研究，结果表明二氧化锰是首选的试剂，它能提供更高的产率、更清洁的反应和更实用的方案。