eicosyl-methyl ether | 122649-90-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: eicosyl-methyl ether
• 英文别名: Eicosyl-methyl-aether；Eicosyl methyl ether；1-methoxyicosane
• CAS: 122649-90-5
• 化学式: C₂₁H₄₄O
• 分子量: 312.58
• InChiKey: IJPKXKFVDWAVHV-UHFFFAOYSA-N

物化性质

• 保留指数：
  2236

计算性质

• 辛醇/水分配系数(LogP)：
  10
• 重原子数：
  22
• 可旋转键数：
  19
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  sodium methylate 、 alkaline earth salt of/the/ methylsulfuric acid 在 甲醇 作用下， 生成 eicosyl-methyl ether
  参考文献：
  名称：

  Dielectric Absorption in Crystalline Long‐Chain Methyl Ethers

  摘要：

  The dielectric properties of three long-chain methyl ethers and two methyl ketones have been measured at frequencies between 5 cps and 2.4×1010 cps, and at different temperatures. No dielectric absorption was detected in the ketones. The ethers were investigated in both the α- and the β-crystalline phases. In the β phase the ethers gave two regions of dielectric absorption, and the energy parameters associated with these absorptions were determined. In the α phase, the methyl ethers give larger dielectric absorption, which occurs mainly in the microwave region, although two of the compounds also give a smaller peak at very low frequencies. The experimental values of the total absorption are in good agreement with the values calculated from the dipole moment. The results suggest that the molecules all contribute to the dielectric absorption, which is in contrast to the situation in β-phase long-chain compounds where it has been suggested that molecular rotation occurs only at imperfections in the crystal lattice.

  DOI：

  10.1063/1.1730046

文献信息

• Coating compositions
  申请人：CIBA-GEIGY AG

  公开号：EP0412933A1

  公开（公告）日：1991-02-13

  The present invention provides coating compositions comprising a) an organic film-forming binder; and b) a corrosion-inhibiting amount of a salt of i) a ketoacid having the formula (I): wherein a is 1,2,3,4 or 5; the R substituents are the same or different and each is hydrogen; halogen; nitro; cyano; CF₃; C₁-C₁₅ alkyl; C₅-C₁₂ cycloalkyl; C₂-C₁₅ alkenyl; C₁-C₁₂ halogenoalkyl; C₁-C₁₂ alkoxy; C₁-C₁₂ thioalkyl; C₆-C₁₂ aryl; C₆-C₁₀ aryloxy; C₇-C₁₂ alkaryl; -CO₂R₁ in which R₁ is a) hydrogen, b) C₁-C₂₀ alkyl optionally inter­rupted by one or more O-, N- or S-atoms, c) C₇-C₁₂ alkaryl or d) C₆-C₁₂ aryl optionally substituted with one or more carboxy groups; -COR₁ in which R₁ has its previous signi­ficance; NR₂R₃ in which R₂ and R₃ are the same or different and each is hydrogen or C₁-C₂₄ alkyl optionally interrupted by one or more O, S or NH moieties; or when a is 2, 3, 4 or 5, two adjacent groups R may be the atoms required to form a fused benzene or cyclo­hexyl ring; and n is an integer from 1 to 10; and ii) an amine of formula II: wherein X, Y and Z are the same or different, and are hydrogen; C₄-C₂₄ alkyl optionally interrupted by one or more O-atoms; phenyl; C₇-C₉ phenylalkyl; C₇-C₉ alkylphenyl; or two of X, Y and Z together with the N-atom to which they are attached form a 5-, 6- or 7-membered heterocyclic residue, which optionally contains a further oxygen, nitrogen or sulphur atom and which is optionally substituted by one or more C₁-C₄ alkyl, amino, hydroxy, carboxy or C₁-C₄ carboxy alkyl groups, and the other of X, Y and Z is hydrogen; provided that X, Y and Z are not simultaneously hydrogen. The salts derived from ketoacids of formula I and amines of formula II are new compounds.

  本发明提供的涂料组合物包括 a) 有机成膜粘合剂；和 b) 一种盐的腐蚀抑制剂。 i) 具有式(I)的酮酸： 其中 a 为 1、2、3、4 或 5；R 取代基相同或不同，且各自为氢；卤素；硝基；氰基；CF₃；C₁-C₁₅ 烷基；C₅-C₁₂ 环烷基；C₂-C₁₅ 烯基；C₁-C₁₂ 卤代烷基；C₁-C₁₂ 烷氧基；C₁-C₁₂ 硫代烷基；C₆-C₁₂ 芳基；C₆-C₁₀ 芳氧基； C₇-C₁₂ 烷芳基；-CO₂R₁，其中 R₁ a) 氢； b) C₁-C₂₀烷基，可选被一个或多个 O-、N- 或 S 原子间断、c) C₇-C₁₂烷芳基或 d) C₆-C₁₂芳基，可选地被一个或多个羧基取代；-COR₁，其中 R₁ 具有其先前的意义； NR₂R₃ ，其中 R₂ 和 R₃ 相同或不同，并且各自为氢或 C₁-C₂₄烷基，可选择被一个或多个 O、S 或 NH 分子打断；或当 a 为 2、3、4 或 5 时，两个相邻基团 R 可为形成融合苯环或环己基环所需的原子；且 n 为 1 至 10 的整数；以及 ii) 式 II 的胺 其中 X、Y 和 Z 相同或不同，并且是氢；C₄-C₂₄ 烷基，可选被一个或多个 O 原子打断；苯基；C₇-C₉ 苯基烷基；C₇-C₉ 烷基苯基；或 X、Y 和 Z 中的两个与它们所连接的 N 原子一起形成 5、6 或 7 元杂环残基，该残基可选地含有另一个氧原子、氮原子或硫原子，并可选地被一个或多个 C₁-C₄ 烷基、氨基、羟基、羧基或 C₁-C₄ 羧基烷基取代，而 X、Y 和 Z 中的另一个是氢；条件是 X、Y 和 Z 不能同时是氢。 由式 I 的酮酸和式 II 的胺衍生的盐是新化合物。
• PYRIDINE COMPOUND AND MEDICINAL USE THEREOF
  申请人：YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD.

  公开号：EP0644191A1

  公开（公告）日：1995-03-22

  A pyridine compound represented by general formula (I) or a pharmaceutical acceptable salt thereof, having the antibacterial effect against Helicobacter pylori, antiulcer effect, the effects of protecting gastrointestinal cells and inhibiting the recrudescence and recurrence of ulcer, and so forth, thus being useful as a medicine, wherein R¹ represents hydrogen, halogen, alkyl, alkoxy, etc.; R² and R³ represent each hydrogen, halogen or alkyl; -P=Q- represents -CH=CH-, -N=CH- or -CH=N-; A represents oxygen, sulfur or NR⁴ (wherein R⁴ represents hydrogen, alkyl, etc.); n represents 0, 1 or 2; B represents oxygen, S(O)p (wherein p represents 0, 1 or 2) or NR⁵ (wherein R⁵ represents hydrogen or alkyl); D represents a single bond, alkylene, etc.; and E represents alkoxyalkyl or -NR⁶R⁷.

  一种由通式(I)代表的吡啶化合物或其药物可接受盐，具有抗幽门螺旋杆菌、抗溃疡、保护胃肠道细胞、抑制溃疡复发和再发等作用，因而可用作药物，其中R¹代表氢、卤素、烷基、烷氧基等；R²和R³分别代表氢、卤素或烷基；-P=Q-代表-CH=CH-、-N=CH-或-CH=N-；A代表氧、硫或NRⅪ。其中 R¹ 代表氢、卤素、烷基、烷氧基等；R² 和 R³ 分别代表氢、卤素或烷基；-P=Q- 代表 -CH=CH-、-N=CH- 或 -CH=N-；A 代表氧、硫或 NR⁴（其中 R⁴ 代表氢、烷基等。n 代表 0、1 或 2；B 代表氧、S(O)p（其中 p 代表 0、1 或 2）或 NR⁵（其中 R⁵ 代表氢或烷基）；D 代表单键、亚烷基等；E 代表烷氧基烷基或 -NR⁶R⁷。
• Process for the preparation of low chloride stabilisers
  申请人：Ciba Specialty Chemicals Holding Inc.

  公开号：EP1097936A1

  公开（公告）日：2001-05-09

  A process for the preparation of a stabiliser mixture containing a low amount of chloride comprising a) 50 - 80 % by weight of tetrakis(2,4-di-tert-butylphenyl)biphenylene diphosphonite and its isomers, b) 5 - 25 % by weight of bis(2,4-di-tert-butylphenyl)biphenylene monophosphonite and its isomers, and c) 5 - 25 % by weight of a tris(2,4-di-tert-butylphenyl) phosphite, and where the sum of components (a), (b) and (c) is not greater than 100 % by weight, by reacting biphenyl under Friedel-Crafts condition with phosphorus trichloride and aluminium trichloride and by reacting the product mixture with 2,4-di-tert-butyl-phenol in the presence of a tertiary amine or an aromatic amine and a solvent, separating the formed two layers, which process comprises treating the solvent layer with water, a base and a desiccant, separating the precipitate from the solution containing the stabiliser mixture and evaporating the solvent.

  一种含有少量氯化物的稳定剂混合物的制备工艺，包括 a) 50-80%（按重量计）的四(2,4-二叔丁基苯基)联苯二膦酸盐及其异构体、 b) 5-25%（按重量计）双(2,4-二叔丁基苯基)联苯单膦酸盐及其异构体，以及 c) 5-25%（按重量计）的三(2,4-二叔丁基苯基)亚磷酸酯、 (a)、(b)和(c)组分的重量总和不大于 100%，方法是在 Friedel-Crafts 条件下，使联苯与三氯化磷和三氯化铝反应，并使产品混合物与 2、4- 二叔丁基苯酚在叔胺或芳香胺和溶剂存在下进行反应，分离形成的两层，该过程包括用水、碱和干燥剂处理溶剂层，从含有稳定剂混合物的溶液中分离沉淀物并蒸发溶剂。
• DISPERSANT, DISPERSION COMPOSITION, AND FIBROUS SHEET
  申请人：MEISEI CHEMICAL WORKS, LTD.

  公开号：EP3135369A1

  公开（公告）日：2017-03-01

  The present invention aims to provide a dispersant and a dispersion composition that exhibit high dispersing ability for nano-carbons such as, in particular, CNTs. The dispersant according to the present invention includes a polyalkylene oxide having a structural unit of the following chemical formula (1). In the chemical formula (1), L1 and L2 are each a straight-chain alkylene group that may have a substituent, Z is a linking group that links L1 and Ar, or alternatively, Z may not be present and L1 and Ar may be linked directly to each other, and Ar is represented by the following chemical formula (1a), (1b), or (1c).

  本发明旨在提供一种对纳米碳（尤其是 CNT）具有高分散能力的分散剂和分散组合物。根据本发明的分散剂包括一种聚环氧烷，其结构单元的化学式如下（1）。 在化学式（1）中 L1 和 L2 各为直链亚烷基，可带有取代基、 Z 是连接 L1 和 Ar 的连接基团，或者可以不含 Z，L1 和 Ar 直接相连，以及 Ar 用以下化学式 (1a)、(1b) 或 (1c) 表示。
• Cationic lipid
  申请人：DAIICHI SANKYO COMPANY, LIMITED

  公开号：US10731159B2

  公开（公告）日：2020-08-04

  The present invention provides a compound represented by the formula (Ia) as a novel cationic lipid that forms a lipid particle and also provides a lipid particle comprising the compound. The present invention further provides a nucleic acid lipid particle containing the lipid particle, and a pharmaceutical composition containing the nucleic acid lipid particle as an active ingredient.

  本发明提供了一种由式（Ia）表示的化合物，作为一种新型阳离子脂质，可形成脂质颗粒，还提供了一种包含该化合物的脂质颗粒。本发明进一步提供了一种含有该脂质颗粒的核酸脂质颗粒，以及一种含有该核酸脂质颗粒作为活性成分的药物组合物。