{2-[(2S,3S,4S,5R,6R)-3,4-Bis-benzyloxy-6-benzyloxymethyl-5-((2S,3R,4S,5S,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-ethyl}-trimethyl-silane | 249925-50-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: {2-[(2S,3S,4S,5R,6R)-3,4-Bis-benzyloxy-6-benzyloxymethyl-5-((2S,3R,4S,5S,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-ethyl}-trimethyl-silane
• CAS: 249925-50-6
• 化学式: C₆₆H₇₆O₁₁Si
• 分子量: 1073.41
• InChiKey: RNSRUMYSBZZLCX-VZKFSQIRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.54
• 重原子数：
  78.0
• 可旋转键数：
  29.0
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  101.53
• 氢给体数：
  0.0
• 氢受体数：
  11.0

反应信息

• 作为反应物：
  描述：

  {2-[(2S,3S,4S,5R,6R)-3,4-Bis-benzyloxy-6-benzyloxymethyl-5-((2S,3R,4S,5S,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-ethyl}-trimethyl-silane 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 生成 (2S,3S,4S,5R,6R)-3,4-Bis-benzyloxy-6-benzyloxymethyl-5-((2S,3R,4S,5S,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-ol
  参考文献：
  名称：

  Synthesis of novel glycosyl phosphate analogues: Derivatives of an acceptor substrate for the Leishmania elongating α-d-mannopyranosylphosphate transferase

  摘要：

  The three structural analogues of dec-9-enyl beta-D-galactosyl-(1-->4)-alpha-D-mannosyl phosphate, comprising thiophosphate, boranophosphate and methylphosphonate derivatives, were prepared via disaccharide H-phosphonate or trichloroacetimidate (for the methylphosphonate synthesis) intermediates. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)01381-7
• 作为产物：
  描述：

  溴甲苯 、 (2S,3R,4S,5R,6R)-2-[(2R,3S,4R,5S,6S)-4,5-Dihydroxy-2-hydroxymethyl-6-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-3-yloxy]-6-hydroxymethyl-tetrahydro-pyran-3,4,5-triol 在 氢氧化钾 作用下， 以 二甲基亚砜 为溶剂， 生成 {2-[(2S,3S,4S,5R,6R)-3,4-Bis-benzyloxy-6-benzyloxymethyl-5-((2S,3R,4S,5S,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-ethyl}-trimethyl-silane
  参考文献：
  名称：

  Synthesis of novel glycosyl phosphate analogues: Derivatives of an acceptor substrate for the Leishmania elongating α-d-mannopyranosylphosphate transferase

  摘要：

  The three structural analogues of dec-9-enyl beta-D-galactosyl-(1-->4)-alpha-D-mannosyl phosphate, comprising thiophosphate, boranophosphate and methylphosphonate derivatives, were prepared via disaccharide H-phosphonate or trichloroacetimidate (for the methylphosphonate synthesis) intermediates. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)01381-7