potassium hydrazincarbonylacetate | 143412-82-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: potassium hydrazincarbonylacetate
• 英文别名: malonic acid monohydrazide; potassium salt；Malonsaeure-monohydrazid; Kaliumsalz；Malonic acid hydrazide monopotassium salt；potassium;3-hydrazinyl-3-oxopropanoate
• CAS: 143412-82-2
• 化学式: C₃H₅N₂O₃*K
• 分子量: 156.183
• InChiKey: UJNSUVWABRIPIH-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -5.88
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  95.2
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  蜕皮激素 、 potassium hydrazincarbonylacetate 在 溶剂黄146 作用下， 以 甲醇 、 水 、 异丙醇 为溶剂， 生成
  参考文献：
  名称：

  Girard derivatization for LC-MS/MS profiling of endogenous ecdysteroids in Drosophila

  摘要：

  Ecdysteroids are potent developmental regulators that control molting, reproduction, and stress response in arthropods. In developing larvae, picogram quantities of individual ecdysteroids and their conjugated forms are present along with milligrams of structural and energy storage lipids. To enhance the specificity and sensitivity of ecdysteroid detection, we targeted the 6-ketone group, which is common to all ecdysteroids, with Girard reagents. Unlike other ketosteroids, during the reaction, Girard hydrazones of ecdysteroids eliminated the C14-hydroxyl group, creating an additional C14-C15 double bond. Dehydrated hydrazones of endogenous ecdysteroids were detected by LC-MS/MS in the multiple reaction monitoring (MRM) mode using two mass transitions: one relied upon neutral loss of a quaternary amine from the Girard T moiety; another complementary transition followed neutral loss of the hydrocarbon chain upon C20-C27 cleavage. We further demonstrated that a combination of Girard derivatization and LC-MS/MS enabled unequivocal detection of three major endogenous hormones at the picogram level in an extract from a single Drosophila pupa.

  DOI：

  10.1194/jlr.d035949
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 一水合肼 作用下， 生成 potassium hydrazincarbonylacetate
  参考文献：
  名称：

  Curtius; Sieber, Chemische Berichte, 1921, vol. 54, p. 1436

  摘要：

  DOI：

文献信息

• Curtius; Sieber, Chemische Berichte, 1921, vol. 54, p. 1436
  作者：Curtius、Sieber

  DOI：——

  日期：——
• Girard derivatization for LC-MS/MS profiling of endogenous ecdysteroids in Drosophila
  作者：Oksana Lavrynenko、Ruslan Nedielkov、Heiko M. Möller、Andrej Shevchenko

  DOI：10.1194/jlr.d035949

  日期：2013.8

  Ecdysteroids are potent developmental regulators that control molting, reproduction, and stress response in arthropods. In developing larvae, picogram quantities of individual ecdysteroids and their conjugated forms are present along with milligrams of structural and energy storage lipids. To enhance the specificity and sensitivity of ecdysteroid detection, we targeted the 6-ketone group, which is common to all ecdysteroids, with Girard reagents. Unlike other ketosteroids, during the reaction, Girard hydrazones of ecdysteroids eliminated the C14-hydroxyl group, creating an additional C14-C15 double bond. Dehydrated hydrazones of endogenous ecdysteroids were detected by LC-MS/MS in the multiple reaction monitoring (MRM) mode using two mass transitions: one relied upon neutral loss of a quaternary amine from the Girard T moiety; another complementary transition followed neutral loss of the hydrocarbon chain upon C20-C27 cleavage. We further demonstrated that a combination of Girard derivatization and LC-MS/MS enabled unequivocal detection of three major endogenous hormones at the picogram level in an extract from a single Drosophila pupa.