N,N'-Bis-<2-hydroxy-2-phenyl-ethyl>-piperazin | 18477-59-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N'-Bis-<2-hydroxy-2-phenyl-ethyl>-piperazin
• 英文别名: N.N'-Di-<2-phenyl-2-hydroxy-ethyl>-piperazin；1,4-Bis(β-phenyl-β-hydroxyethyl)piperazin；1,1'-diphenyl-2,2'-piperazine-1,4-diyl-bis-ethanol；1,4-bis-(β-hydroxy-phenethyl)-piperazine；1,4-Bis-(β-hydroxy-phenaethyl)-piperazin；N1,N4-di(2-phenylethyl-2-ol)piperazine；2,2'-(Piperazine-1,4-diyl)bis(1-phenylethanol)；2-[4-(2-hydroxy-2-phenylethyl)piperazin-1-yl]-1-phenylethanol
• CAS: 18477-59-3
• 化学式: C₂₀H₂₆N₂O₂
• 分子量: 326.439
• InChiKey: UPPPVVFXYBFITJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  46.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  氧化苯乙烯 、 Piperazin-hexahydrat 在 乙醇 作用下， 生成 N,N'-Bis-<2-hydroxy-2-phenyl-ethyl>-piperazin
  参考文献：
  名称：

  [关于苯乙烯的氨解，制备苯基氨基乙醇。第四部分 环氧化物的氨解]。

  摘要：

  DOI：

  10.1002/ardp.19592921212

文献信息

• Aralkyl-alcohol peiperazine derivatives adn their uses as antidepressant
  申请人：Li Jianqi

  公开号：US20050267121A1

  公开（公告）日：2005-12-01

  Aryl alkanol piperazine derivatives of the formula and pharmaceutical compositions comprising the same. Also disclosed are methods for treating depression using the pharmaceutical compositon. Compounds of the invention have excellent dual inhibitory actions to the uptake of the mono-amines neurotransmitter, good antidepressant activities and minor side effects.

  Aryl alkanol piperazine衍生物的公式和包含它们的药物组合物。还公开了使用药物组合物治疗抑郁症的方法。本发明的化合物对单胺类神经递质的摄取具有优良的双重抑制作用，具有良好的抗抑郁活性和较小的副作用。
• Chemical mechanical planarization for tungsten-containing substrates
  申请人：AIR PRODUCTS AND CHEMICALS, INC.

  公开号：EP2779217A2

  公开（公告）日：2014-09-17

  Chemical mechanical polishing (CMP) compositions for polishing tungsten or tungsten-containing substrates comprise an abrasive, at least one solid catalyst, a chemical additive selected from the groups consisting of piperazine derivatives, salts of cyanate, and combinations thereof; and a liquid carrier. Systems and processes use the aqueous formulations for polishing tungsten or tungsten-containing substrates.

  用于抛光钨或含钨基材的化学机械抛光（CMP）组合物包括磨料、至少一种固体催化剂、一种选自哌嗪衍生物、氰酸盐及其组合的化学添加剂；以及一种液体载体。系统和工艺使用水性制剂抛光钨或含钨基材。
• Laundry detergent compositions containing a polymer for fabric appearance improvement
  申请人：The Procter & Gamble Company

  公开号：US20010056058A1

  公开（公告）日：2001-12-27

  Detergent compositions and fabric conditioning compositions which include from about 0.01% to about 5.0%, by weight, of polyelectolyte complexes having a compatible charge-balancing polymeric anion with at least 3 anionic groups and a total net charge of at least 4 negative charges.

  洗涤剂组合物和织物护理剂组合物，其中包括约 0.01%至约 5.0%（按重量计）的聚电解质复合物，该复合物具有相容的电荷平衡聚合物阴离子，其阴离子基团至少有 3 个，总净电荷至少有 4 个负电荷。
• Polyelectrolyte complexes and a method for production thereof
  申请人：——

  公开号：US20030078185A1

  公开（公告）日：2003-04-24

  Polyelectrolyte complexes of cationic and anionic polymers which consist of (a) cationic condensates of (i) at least one amine and (ii) a crosslinking agent from the group consisting of epihalohydrins, bishalohydrins of diols, bishalohydrins of polyalkylene glycols, bishalohydrins of polytetrahydrofurans, alkylene dihalides, alkylene trihalides, bisepoxides, trisepoxides, tetraepoxides and/or mixtures of said compounds, and/or quaternized cationic condensates of (i) and (ii), and (b) anionic compounds containing at least three anionic groups and have a charge ratio between anionic and cationic polymers of from 0.01 to 20, and a process for the preparation of the polylectrolyte complexes by mixing the cationic condensates (a) with anionic compounds (b).

  阳离子和阴离子聚合物的聚电解质复合物，由以下物质组成 (a) (i)至少一种胺和(ii)一种交联剂的阳离子缩合物，交联剂包括表卤代烃、二元醇的双卤代烃、聚亚烷基二醇的双卤代烃聚四氢呋喃的双卤水酐、亚烷基二卤化物、亚烷基三卤化物、双环氧化物、三环氧化物、 四环氧化物和/或上述化合物的混合物，和/或(i)和(ii)的季铵化阳离子缩合物，以及 (b) 至少含有三个阴离子基团的阴离子化合物 以及将阳离子缩合物（a）与阴离子化合物（b）混合制备聚电解质复合物的工艺。
• Method for manufacturing laundry additive article
  申请人：——

  公开号：US20030118730A1

  公开（公告）日：2003-06-26

  A method for manufacturing a laundry additive article wherein a polymerizable or crosslinkable dye or particulate soil absorber is applied to one face of a substrate web and a cross-linker is separately applied to the coating of the dye or particulate soil absorber to cross-link the dye or particulate soil absorber on the substrate such that the dye or particulate soil absorber does not dissolve in the wash water. In accordance with one embodiment, the dye or particulate soil absorber and the cross-linker are applied as aqueous based solutions. Other laundry additives may be applied to the substrate using other coating techniques and particularly as a waxy or hot melt composition.

  一种制造洗衣添加剂制品的方法，其中将可聚合或可交联的染料或微粒土壤吸收剂涂在基材网的一个面上，并将交联剂分别涂在染料或微粒土壤吸收剂的涂层上，以交联基材上的染料或微粒土壤吸收剂，从而使染料或微粒土壤吸收剂不溶解在洗涤水中。根据一个实施方案，染料或微粒土壤吸收剂和交联剂以水基溶液的形式使用。其他洗衣添加剂可采用其他涂布技术，特别是以蜡状或热熔组合物的形式涂布到基材上。