| 808109-13-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 808109-13-9
• 化学式: C₁₉H₂₈O₆
• 分子量: 352.428
• InChiKey: PMQWBTABFZLMQH-AJVNXVRISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.91
• 重原子数：
  25.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  71.06
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  在 Pt/Al₂O₃ 氢气 作用下， 以 正己烷 为溶剂， 反应 24.0h， 生成
  参考文献：
  名称：

  Stereoselective hydrogenation of conjugate diene directed by hydroxy group and asymmetric synthesis of deoxypolypropionate units

  摘要：

  Optically active cyclic compounds carrying a conjugate diene and two hydroxy groups were prepared through the intramolecular Buchner reaction with a chiral tether and succeeding stereoselective conversion. Hydrogenation of the diene in the first step was not regio-selective but resulted in three regioisomeric monoenes. Nevertheless. the final saturated product carrying two stereogenic centers could be obtained in 98% stereochemical purity on further hydrogenation under optimized conditions. The high stereoselectivity throughout the multiple pathways is attributable to the effective direction by the hydroxy group. Ring cleavage of the produced stereochemically pure seven-membered ring compounds successfully resulted in synthetic intermediates for deoxypolypropionates. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.02.128
• 作为产物：
  描述：

  (2R,4S)-4-((R)-7-Hydroxymethyl-3,5-dimethyl-cyclohepta-1,3,5-trienyloxy)-pentan-2-ol 在 吡啶 、 4-二甲氨基吡啶 、 potassium fluoride 、 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 反应 1.67h， 生成
  参考文献：
  名称：

  Stereoselective hydrogenation of conjugate diene directed by hydroxy group and asymmetric synthesis of deoxypolypropionate units

  摘要：

  Optically active cyclic compounds carrying a conjugate diene and two hydroxy groups were prepared through the intramolecular Buchner reaction with a chiral tether and succeeding stereoselective conversion. Hydrogenation of the diene in the first step was not regio-selective but resulted in three regioisomeric monoenes. Nevertheless. the final saturated product carrying two stereogenic centers could be obtained in 98% stereochemical purity on further hydrogenation under optimized conditions. The high stereoselectivity throughout the multiple pathways is attributable to the effective direction by the hydroxy group. Ring cleavage of the produced stereochemically pure seven-membered ring compounds successfully resulted in synthetic intermediates for deoxypolypropionates. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.02.128