5-(2,2-Dimethylpropyl)oxolan-2-one | 122776-51-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: 5-(2,2-Dimethylpropyl)oxolan-2-one
• CAS: 122776-51-6
• 化学式: C₉H₁₆O₂
• 分子量: 156.225
• InChiKey: JZKIRDRGEIBCJO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  perpentene-4 oate de tertiobutyle 在 叔丁基(氯)汞 作用下， 以 二甲基亚砜 为溶剂， 以48%的产率得到5-(2,2-Dimethylpropyl)oxolan-2-one
  参考文献：
  名称：

  Russell, Glen A.; Guo, Deliang; Baik, Woonphil, Heterocycles, 1989, vol. 28, # 1, p. 143 - 146

  摘要：

  DOI：

文献信息

• 5-CHLORO-2-DIFLUOROMETHOXYPHENYL PYRAZOLOPYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF
  申请人：Genentech, Inc.

  公开号：US20150336962A1

  公开（公告）日：2015-11-26

  Compounds of Formula (00A) and methods of use as Janus kinase inhibitors are described herein.

  这里描述了化合物的公式（00A）及其作为Janus激酶抑制剂的使用方法。
• 5-CHLORO-2-DIFLUOROMETHOXYPHENYL PYRAZOLOPYRIMIDINE COMPOUNDS,COMPOSITIONS AND METHODS OF USE THEREOF
  申请人：Genentech, Inc.

  公开号：US20160237086A1

  公开（公告）日：2016-08-18

  Compounds of Formula (00A) and methods of use as Janus kinase inhibitors are described herein.

  本文描述了化学式(00A)的化合物以及作为Janus激酶抑制剂的使用方法。
• Methods for treating ulcerative colitis using 3-((1R,3s,5S)-3-((7-((5-methyl-1H-pyrazol-3-yl)amino)-1,6-naphthyridin-5-yl)amino)-8-azabicyclo[3.2.1]octan-8-yl)propanenitrile
  申请人：THERAVANCE BIOPHARMA R&D IP, LLC

  公开号：US10947254B2

  公开（公告）日：2021-03-16

  Disclosed are methods for treating ulcerative colitis using a compound of the formula: or a pharmaceutically-acceptable salt thereof.

  所公开的是使用式中化合物治疗溃疡性结肠炎的方法： 或其药学上可接受的盐。
• NAPHTHYRIDINE COMPOUNDS AS JAK KINASE INHIBITORS
  申请人：THERAVANCE BIOPHARMA R&D IP, LLC

  公开号：US20160347772A1

  公开（公告）日：2016-12-01

  The invention provides compounds of formula (I): wherein the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are inhibitors of JAK kinases. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat inflammatory bowel diseases, and processes and intermediates useful for preparing such compounds.
• SILICON-CONTAINING RESIST UNDERLAYER FILM-FORMING COMPOSITION HAVING ORGANIC GROUP HAVING ALIPHATIC POLYCYCLIC STRUCTURE
  申请人：NISSAN CHEMICAL INDUSTRIES, LTD.

  公开号：US20170153549A1

  公开（公告）日：2017-06-01

  A resist underlayer film-forming composition for lithography having an aliphatic polycyclic structure including, as a silane, a hydrolyzable silane, a hydrolysis product thereof, a hydrolysis-condensation product thereof, or a combination thereof, in which the aliphatic polycyclic structure is a structure which a hydrolyzable silane of Formula (1): R 1 a R 2 b Si(R 3 ) 4−(a+b) Formula (1) (where R 1 is an organic group having an aliphatic polycyclic structure and bonded to a Si atom through a Si—C bond; R 3 is an ethoxy group; a is an integer of 1; b is an integer of 0 to 2; and a+b is an integer of 1 to 3) has, or a structure included in a compound added as an aliphatic polycyclic compound, an aliphatic polycyclic dicarboxylic acid, or an aliphatic polycyclic dicarboxylic acid anhydride, each optionally having a double bond, a hydroxy group, or an epoxy group.