7-(((4-chlorophenyl)amino)(phenyl)methyl)quinolin-8-ol | 117091-29-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7-(((4-chlorophenyl)amino)(phenyl)methyl)quinolin-8-ol
• 英文别名: 7-[(4-chlorophenylamino)phenylmethyl]quinolin-8-ol；NSC84090；7-[α-(4-chloro-anilino)-benzyl]-quinolin-8-ol；7-[α-(4-Chlor-anilino)-benzyl]-chinolin-8-ol；7-[(4-Chloroanilino)-phenylmethyl]quinolin-8-ol
• CAS: 117091-29-9
• 化学式: C₂₂H₁₇ClN₂O
• 分子量: 360.843
• InChiKey: YDDMHKBSMKWOOY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  45.2
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  8-羟基喹啉 、 苯甲醛 、 对氯苯胺 在 乙醇 作用下， 生成 7-(((4-chlorophenyl)amino)(phenyl)methyl)quinolin-8-ol
  参考文献：
  名称：

  Sen; Saxena, Journal of the Indian Chemical Society, 1956, vol. 33, p. 62

  摘要：

  DOI：

文献信息

• METHODS OF TREATING CREATINE TRANSPORTER DEFICIENCY
  申请人：Jnana Therapeutics, Inc.

  公开号：US20210299070A1

  公开（公告）日：2021-09-30

  Disclosed are methods of treating creatine transporter deficiency, comprising administering to a mammal in need thereof a therapeutically effective amount of a compound that increases transport of a substrate by a mutant or wild-type creatine transporter. Also disclosed are methods of increasing transport of guanidinoacetic acid or a salt thereof across the blood-brain barrier of a mammal, and methods of decreasing accumulation or the concentration of guanidinoacetic acid or a salt thereof in a mammalian cell.

  揭示了治疗肌酸转运蛋白缺乏症的方法，包括向需要的哺乳动物施用增加突变型或野生型肌酸转运蛋白对底物转运的化合物的治疗有效量。还披露了增加鸟氨酸乙酸或其盐跨越哺乳动物血脑屏障的方法，以及减少哺乳动物细胞中鸟氨酸乙酸或其盐的积累或浓度的方法。
• SMALL MOLECULES TARGETING MUTANT MAMMALIAN PROTEINS
  申请人：Jnana Therapeutics, Inc.

  公开号：US20210300898A1

  公开（公告）日：2021-09-30

  Disclosed are compounds, compositions, and methods useful for treating or preventing a disease or disorder associated with a mutation in a protein.

  揭示了用于治疗或预防与蛋白质突变相关的疾病或紊乱的化合物、组合物和方法。
• Small molecule inhibitors of botulinum neurotoxins
  申请人：Roxas-Duncan Virginia I.

  公开号：US10301265B2

  公开（公告）日：2019-05-28

  The invention provides potent quinolinol-based BoNT/A small-molecule inhibitors of botulinum neurotoxins, in particular of Clostridium botulinum serotype A neurotoxins. The invention also provides methods of using these small-molecule inhibitors to inhibit infections by Clostridium botulinum, as well as, methods of preventing infections by Clostridium botulinum through materials that may be ingested.

  本发明提供了肉毒杆菌神经毒素，特别是肉毒杆菌血清型A神经毒素的强效喹啉醇基BoNT/A小分子抑制剂。本发明还提供了使用这些小分子抑制剂抑制肉毒梭菌感染的方法，以及通过可能摄入的材料预防肉毒梭菌感染的方法。
• SMALL MOLECULE INHIBITORS OF BOTULINUM NEUROTOXINS
  申请人：Roxas-Duncan Virginia I.

  公开号：US20110294848A1

  公开（公告）日：2011-12-01

  The invention provides potent quinolinol-based BoNT/A small-molecule inhibitors of botulinum neurotoxins, in particular of Clostridium botulinum serotype A neurotoxins. The invention also provides methods of using these small-molecule inhibitors to inhibit infections by Clostridium botulinum , as well as, methods of preventing infections by Clostridium botulinum through materials that may be ingested.
• [EN] SMALL MOLECULES TARGETING MUTANT MAMMALIAN PROTEINS<br/>[FR] PETITES MOLÉCULES CIBLANT DES PROTÉINES MUTANTES DE MAMMIFÈRES
  申请人：JNANA THERAPEUTICS INC

  公开号：WO2020061476A1

  公开（公告）日：2020-03-26

  Disclosed are compounds, compositions, and methods useful for treating or preventing a disease or disorder associated with mutation in a protein. One aspect of the invention provides compounds, compositions, and methods useful for treating or preventing a disease or disorder associated with a SLC6A8 mutation.