4-(4-bromophenyl)-5,6,7,8-tetrahydro-7,7-dimethyl-5-oxo-2-(phenylamino)quinoline-3-carbonitrile | 1229931-76-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-(4-bromophenyl)-5,6,7,8-tetrahydro-7,7-dimethyl-5-oxo-2-(phenylamino)quinoline-3-carbonitrile
• CAS: 1229931-76-3
• 化学式: C₂₄H₂₀BrN₃O
• 分子量: 446.346
• InChiKey: FJOUYEZWIXGDCX-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  异氰酸苯酯 、 2-amino-5,6,7,8-tetrahydro-4-(4-bromophenyl)-7,7-dimethyl-5-oxo-4H-chromene-3-carbonitrile 在 碘 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.33h， 以81%的产率得到4-(4-bromophenyl)-5,6,7,8-tetrahydro-7,7-dimethyl-5-oxo-2-(phenylamino)quinoline-3-carbonitrile
  参考文献：
  名称：

  Iodine-Promoted Domino Reaction Leading to N-Substituted 2-Aminoquinoline-3-carbonitriles under Microwave Irradiation

  摘要：

  A new iodine-promoted domino reaction of 2-aminochromene-3-carbonitriles with various isocyanates is described, and a set of polyfunctionalized N-substituted 2-aminoquinoline-3-carbonitriles with high regioselectivity were successfully synthesized under microwave heating. In this reaction, the ring-opening/recyclization process occurs unexpectedly at the ring of 4H-pyran with different isocyanates.

  DOI：

  10.1021/cc1000192