ethyl 4-(2,8-dimethylquinolin-4-ylamino)benzoate dihydrochloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: ethyl 4-(2,8-dimethylquinolin-4-ylamino)benzoate dihydrochloride
• 英文别名: ethyl 4-[(2,8-dimethylquinolin-4-yl)amino]benzoate;hydrochloride
• 化学式: C₂₀H₂₀N₂O₂*2ClH
• 分子量: 393.313
• InChiKey: FJQCZNQYSNDYCV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.19
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  51.2
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  ethyl 4-(2,8-dimethylquinolin-4-ylamino)benzoate dihydrochloride 在 NaOHli 作用下， 以 乙醇 、 水 为溶剂， 反应 4.0h， 以91%的产率得到4-(2,8-dimethylquinolin-4-ylamino)benzoic acid dihydrochloride
  参考文献：
  名称：

  Synthesis and transformations of 2- and 4-(2-Methylquinolin-4-ylamino)benzoic acids and ethyl 4-(2-methylquinolin-4-ylamino)benzoates and their fluorescent properties

  摘要：

  2- and 4-(2-Methylquinolin-4-ylamino)benzoic acids and ethyl 4-(2-methylquinolin-4-ylamino)-benzoates having a substituent in the 6(8)-position of the quinoline ring were synthesized by reaction of the corresponding substituted 4-chloro-2-methylquinolines with 2- and 4-aminobenzoic acids and ethyl 4-aminobenzoate. Intramolecular cyclization of 2-(2-methylquinolin-4-ylamino)benzoic acids in concentrated sulfuric acid gave 7-hydroxy-6-methyldibenzo[b,h][1,6]naphthyridines, and ethyl 4-(2-methylquinolin-4-ylamino)benzoates were converted into 4-(2-methylquinolin-4-ylamino)benzoic acids by alkaline hydrolysis.

  DOI：

  10.1134/s1070428007070196
• 作为产物：
  描述：

  4-氯-2,8-二甲基喹啉 、 苯佐卡因 在 盐酸 作用下， 以 乙醇 、 水 为溶剂， 反应 20.0h， 以87%的产率得到ethyl 4-(2,8-dimethylquinolin-4-ylamino)benzoate dihydrochloride
  参考文献：
  名称：

  Synthesis and transformations of 2- and 4-(2-Methylquinolin-4-ylamino)benzoic acids and ethyl 4-(2-methylquinolin-4-ylamino)benzoates and their fluorescent properties

  摘要：

  2- and 4-(2-Methylquinolin-4-ylamino)benzoic acids and ethyl 4-(2-methylquinolin-4-ylamino)-benzoates having a substituent in the 6(8)-position of the quinoline ring were synthesized by reaction of the corresponding substituted 4-chloro-2-methylquinolines with 2- and 4-aminobenzoic acids and ethyl 4-aminobenzoate. Intramolecular cyclization of 2-(2-methylquinolin-4-ylamino)benzoic acids in concentrated sulfuric acid gave 7-hydroxy-6-methyldibenzo[b,h][1,6]naphthyridines, and ethyl 4-(2-methylquinolin-4-ylamino)benzoates were converted into 4-(2-methylquinolin-4-ylamino)benzoic acids by alkaline hydrolysis.

  DOI：

  10.1134/s1070428007070196

文献信息

• Ahmad; Bhargava; Kishor, Pharmazie, 1981, vol. 36, # 6, p. 403 - 404
  作者：Ahmad、Bhargava、Kishor、Shanker

  DOI：——

  日期：——
• Synthesis and transformations of 2- and 4-(2-Methylquinolin-4-ylamino)benzoic acids and ethyl 4-(2-methylquinolin-4-ylamino)benzoates and their fluorescent properties
  作者：A. A. Avetisyan、I. L. Aleksanyan、L. P. Ambartsumyan

  DOI：10.1134/s1070428007070196

  日期：2007.7

  2- and 4-(2-Methylquinolin-4-ylamino)benzoic acids and ethyl 4-(2-methylquinolin-4-ylamino)-benzoates having a substituent in the 6(8)-position of the quinoline ring were synthesized by reaction of the corresponding substituted 4-chloro-2-methylquinolines with 2- and 4-aminobenzoic acids and ethyl 4-aminobenzoate. Intramolecular cyclization of 2-(2-methylquinolin-4-ylamino)benzoic acids in concentrated sulfuric acid gave 7-hydroxy-6-methyldibenzo[b,h][1,6]naphthyridines, and ethyl 4-(2-methylquinolin-4-ylamino)benzoates were converted into 4-(2-methylquinolin-4-ylamino)benzoic acids by alkaline hydrolysis.