4-iodo-7a-methyl-6,7-dihydro-3H-2-benzofuran-1,5-dione | 925681-25-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: 4-iodo-7a-methyl-6,7-dihydro-3H-2-benzofuran-1,5-dione
• CAS: 925681-25-0
• 化学式: C₉H₉IO₃
• 分子量: 292.073
• InChiKey: WGUCEFHWBMQPFC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  、 4-iodo-7a-methyl-6,7-dihydro-3H-2-benzofuran-1,5-dione 在 四(三苯基膦)钯 copper(l) iodide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以94%的产率得到(7aR,10aR)-2-tert-butyl-4-[2-[tert-butyl(diphenyl)silyl]oxyethyl]-7a-methyl-7,10-dihydro-6H-furo[3,4-i]chromene-5,8-dione
  参考文献：
  名称：

  The development and scope of a versatile tandem Stille-oxa-electrocyclization reaction

  摘要：

  A palladium-catalyzed tandem Stille-oxa-electrocyclization reaction has been developed for the convergent preparation of highly substituted polycyclic pyran systems. The strategy presented in this letter is an alternative to the known methods for constructing similar pyran systems. The substrate scope of this diastereoselective transformation is explored. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.11.097
• 作为产物：
  描述：

  7a-Methyl-7,7a-dihydro-2-benzofuran-1,5(3H,6H)-dione 在 一氯化碘 作用下， 以 二氯甲烷 为溶剂， 反应 4.0h， 以75%的产率得到4-iodo-7a-methyl-6,7-dihydro-3H-2-benzofuran-1,5-dione
  参考文献：
  名称：

  The development and scope of a versatile tandem Stille-oxa-electrocyclization reaction

  摘要：

  A palladium-catalyzed tandem Stille-oxa-electrocyclization reaction has been developed for the convergent preparation of highly substituted polycyclic pyran systems. The strategy presented in this letter is an alternative to the known methods for constructing similar pyran systems. The substrate scope of this diastereoselective transformation is explored. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.11.097