(2-Amino-4,5-dimethoxyphenyl)-thiophen-2-ylmethanone | 121638-94-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2-Amino-4,5-dimethoxyphenyl)-thiophen-2-ylmethanone
• CAS: 121638-94-6
• 化学式: C₁₃H₁₃NO₃S
• 分子量: 263.317
• InChiKey: HYGPAIUJCZZNME-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  89.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (2-Amino-4,5-dimethoxyphenyl)-thiophen-2-ylmethanone 在 dirhodium tetraacetate 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 甲苯 为溶剂， 生成 ethyl 5,6-dimethoxy-3-(2-thienyl)indole-2-carboxylate
  参考文献：
  名称：

  Construction of Heterocyclic Compounds by Use of α-Diazophosphonates:  New One-Pot Syntheses of Indoles and Isocoumarins

  摘要：

  [GRAPHICS]alpha-Diazophosphonates, which have extremely useful properties from a synthetic point of view, are disclosed as 1,1-ambiphilic one-carbon building blocks for one-pot construction of various heterocyclic compounds. They are easily prepared and have higher stability by the effect of the phosphoryl group than corresponding alpha-diazocarbonyl compounds. Using this synthon, we have developed a novel, mild, and efficient synthetic method of 2,3-disubstituted indoles and 3,4-disubstituted isocoumarins.

  DOI：

  10.1021/ol025916k
• 作为产物：
  描述：

  二甲氧基乙酰苯胺 在 盐酸 、 三氯化铝 作用下， 以 二硫化碳 、 溶剂黄146 为溶剂， 反应 23.0h， 生成 (2-Amino-4,5-dimethoxyphenyl)-thiophen-2-ylmethanone
  参考文献：
  名称：

  Pharmacomodulation d'arylcétones thiophéniques anti-agrégantes plaquettaires

  摘要：

  DOI：

  10.1016/0223-5234(88)90092-x

文献信息

• VARACHE-BERANGER, MARTINE;NUHRICH, ALAIN;DEVAUX, GUY, EUR. J. MED. CHEM., 23,(1988) N, C. 501-510
  作者：VARACHE-BERANGER, MARTINE、NUHRICH, ALAIN、DEVAUX, GUY

  DOI：——

  日期：——
• Construction of Heterocyclic Compounds by Use of α-Diazophosphonates:  New One-Pot Syntheses of Indoles and Isocoumarins
  作者：Yoshinori Nakamura、Tatsuzo Ukita

  DOI：10.1021/ol025916k

  日期：2002.7.1

  [GRAPHICS]alpha-Diazophosphonates, which have extremely useful properties from a synthetic point of view, are disclosed as 1,1-ambiphilic one-carbon building blocks for one-pot construction of various heterocyclic compounds. They are easily prepared and have higher stability by the effect of the phosphoryl group than corresponding alpha-diazocarbonyl compounds. Using this synthon, we have developed a novel, mild, and efficient synthetic method of 2,3-disubstituted indoles and 3,4-disubstituted isocoumarins.
• Pharmacomodulation d'arylcétones thiophéniques anti-agrégantes plaquettaires
  作者：Martine Varache-Béranger、Alain Nuhrich、Guy Devaux

  DOI：10.1016/0223-5234(88)90092-x

  日期：1988.11