(S)-(+)-2-甲基环辛酮 | 77857-44-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: (S)-(+)-2-甲基环辛酮
• 英文名称: (S)-(+)-2-methylcyclooctanone
• 英文别名: (2S)-2-methylcyclooctan-1-one
• CAS: 77857-44-4
• 化学式: C₉H₁₆O
• 分子量: 140.225
• InChiKey: MJFJFHJQZCMMKL-QMMMGPOBSA-N

物化性质

• 沸点：
  50 °C(Press: 10 Torr)
• 密度：
  0.885±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  trans-2-methylcyclooctanol 在 chromium(VI) oxide 、 硫酸 作用下， 以75%的产率得到(S)-(+)-2-甲基环辛酮
  参考文献：
  名称：

  Dynamic kinetic resolution in the microbial reduction of α-monosubstituted β-oxoesters: the reduction of 2-carbethoxycycloheptanone and 2-carbethoxy-cyclooctanone

  摘要：

  The microbial reduction of the title compounds by various yeasts or filamentous fungi strains affords the corresponding (1S,2R)- and/or (1S,2S)-hydroxyesters in good yield and ee. The determination of their absolute configuration was achieved by transformation into known 2-methylcycloalkanone stereoisomers. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0957-4166(97)00171-7

文献信息

• Aminotetraline and aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
  申请人：AbbVie Deutschland GmbH & Co. KG

  公开号：US20150111875A1

  公开（公告）日：2015-04-23

  The present invention relates to aminotetraline and aminoindane derivatives of the formula (I) or a physiologically tolerated salt thereof. The invention relates to pharmaceutical compositions comprising such aminotetraline and aminoindane derivatives, and the use of such aminotetraline and aminoindane derivatives for therapeutic purposes. The aminotetraline and aminoindane derivatives are GlyT1 inhibitors.

  本发明涉及公式(I)的氨基四氢萘和氨基茚衍生物或其生理耐受的盐。该发明涉及包含此类氨基四氢萘和氨基茚衍生物的药物组合物，以及利用这些氨基四氢萘和氨基茚衍生物进行治疗目的的用途。氨基四氢萘和氨基茚衍生物是GlyT1抑制剂。
• Enantioface-differentiating enzymatic hydrolysis of α-substituted cycloalkanone enol esters
  作者：Hiromichi Ohta、Kazutsugu Matsumoto、Seiji Tsutsumi、Tamiko Ihori

  DOI：10.1039/c39890000485

  日期：——

  2-Substituted 1-acyloxycycloalkenes have been hydrolysed with the aid of a micro-organism to afford optically active 2-substituted cycloalkanones.

  2-取代的1-酰氧基环烯烃已经在微生物的帮助下水解，得到了光学活性的2-取代的环烷酮。
• Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy
  申请人：AbbVie Deutschland GmbH & Co. KG

  公开号：US20150111867A1

  公开（公告）日：2015-04-23

  The present invention relates to aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives of the formula (I) or a physiologically tolerated salt thereof The invention relates to pharmaceutical compositions comprising such aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, and the use of such aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquin oline derivatives for therapeutic purposes. The aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives are GlyT1 inhibitors.

  本发明涉及氨基色酮、氨基硫代色酮和氨基-1,2,3,4-四氢喹啉衍生物的化学式（I）或其生理耐受盐。该发明涉及包括这种氨基色酮、氨基硫代色酮和氨基-1,2,3,4-四氢喹啉衍生物的药物组合物，以及利用这种氨基色酮、氨基硫代色酮和氨基-1,2,3,4-四氢喹啉衍生物进行治疗目的的用途。这些氨基色酮、氨基硫代色酮和氨基-1,2,3,4-四氢喹啉衍生物是GlyT1抑制剂。
• Enantioselective alkylation of ketones via chiral, nonracemic lithioenamines. An asymmetric synthesis of .alpha.-alkyl and .alpha.,.alpha.'-dialkyl cyclic ketones
  作者：A. I. Meyers、Donald R. Williams、Gary W. Erickson、Steven White、Melvin Druelinger

  DOI：10.1021/ja00401a028

  日期：1981.6
• Matsumoto, Kazutsugu; Tsutsumi, Seiji; Ihori, Tamiko, Journal of the American Chemical Society, 1990, vol. 112, # 26, p. 9614 - 9619
  作者：Matsumoto, Kazutsugu、Tsutsumi, Seiji、Ihori, Tamiko、Ohta, Hiromichi

  DOI：——

  日期：——