4-壬酰基吡啶 | 146690-00-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 4-壬酰基吡啶
• 英文名称: octyl pyridin-4-yl ketone
• 英文别名: 1-(Pyridin-4-yl)nonan-1-one；1-pyridin-4-ylnonan-1-one
• CAS: 146690-00-8
• 化学式: C₁₄H₂₁NO
• 分子量: 219.327
• InChiKey: BYKOCMLOXFYMFQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  16
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  30
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2933399090

反应信息

• 作为反应物：
  描述：

  4-壬酰基吡啶 在 palladium 10% on activated carbon 、 氢气 作用下， 以 甲醇 、 1,2-二氯乙烷 为溶剂， 20.0 ℃ 、275.8 kPa 条件下， 反应 4.5h， 以97%的产率得到α-octyl-4-pyridinemethanol hydrochloride
  参考文献：
  名称：

  Controlling chemoselective transformations of 4-acylpyridines via a Pd–C catalytic hydrodechlorination–hydrogenation

  摘要：

  A novel Pd-C catalytic hydrodechlorination-hydrogenation was developed for a multi-step one-pot transformation of 4-acylpyridines. Under the selected conditions, 4-benzoylpyridines and 4-alkanoylpyridines were chemoselectively converted into the corresponding 4-benzylpiperidine hydrochlorides and alpha-alkyl-4-piperidinemethanol hydrochlorides, respectively. This catalytic method was performed simply by an addition of 1 equiv of CICH2CHCl2 to the conventional hydrogenation system and directly gave the crystalline piperidine hydrochlorides in practical quantitative yields. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.12.017
• 作为产物：
  描述：

  4-氰基吡啶 、 正辛基镁溴盐 以 乙醚 为溶剂， 以72.2%的产率得到4-壬酰基吡啶
  参考文献：
  名称：

  Cleavage of 4-Nitrophenyl Diphenyl Phosphate by Isomeric Quaternary Pyridinium Ketoximes - How Can Structure and Lipophilicity of Functional Surfactants Influence Their Reactivity in Micelles and Microemulsions?

  摘要：

  两种异构阳离子表面活性剂分别为4-[1-(羟亚胺)烷基]-1-甲基吡啶溴化物（1）和1-烷基-4-[1-(羟亚胺)乙基]吡啶溴化物（2），它们是含有亲核羟亚胺基团的两性分子。它们在亲核功能相对于极性头基团和疏水烷基链的位置上有所不同。通过从1和2生成的羟肟阴离子对4-硝基苯二苯磷酸三酯（PNPDPP）的裂解被用作模型反应，以研究功能性表面活性剂的结构和亲脂性对其在胶束和微乳中的反应性的影响。在正十六烷基三甲基溴化铵（CTAB）的阳离子胶束、非离子胶束（Triton X-100和Brij 35）以及o/w型微乳（异辛烷/磷酸缓冲液/CTAB和正丁醇）中对模型反应的研究表明，亲脂性是影响功能性表面活性剂在纳米聚集体中定位和反应性的最重要因素。

  DOI：

  10.1135/cccc20061642

文献信息

• Organic solvent-soluble metal-azo and metal-azomethine dyes
  申请人：MINNESOTA MINING AND MANUFACTURING COMPANY

  公开号：EP0591016A1

  公开（公告）日：1994-04-06

  Metal-azo dyes with excellent solubility in organic media are provided. The metal-containing dyes of the present invention have a nucleus of the formula: wherein:    Z₁ and Z₂ each independently represents an arene nucleus having from 5 to 14 ring atoms;    G₁ and G₂ each independently represent a metal ligating group, wherein G₁ and G₂ may be contained within or pendant from at least one of Z₁ and Z₂;    R represents a hydrogen atom, a halogen atom, an alkyl group, an acylamino group, an alkoxy group, a sulfonamido group, an aryl group, a thiol group, an alkylthio group, an arylthio group, an alkylamino group, an arylamino group, an amino group, an alkoxycarbonyl group, an acyloxy group, a nitro group, a cyano group, an alkylsulfonyl, an arylsulfonyl group, an alkylsulfoxyl group, an arylsulfoxyl group, an aryloxy group, a hydroxy group, a thioamido group, a carbamoyl group, a sulfamoyl group, a formyl group, an acyl group, a ureido group, an aryloxycarbonyl group, a silyl group, or a sulfoalkoxy group;    L₁ represents a trialkyl or triaryl phosphine ligand; or L₁ represents a pyridine ring group free of free-radically polymerizable functionality, and free of substitution at the 2- and 6- positions and at least one of the 3-, 4-, 5-positions of the pyridine ring group are substituted with R₁, wherein;    R₁ represents an alkyl group, an acylamino group, an alkoxy group, a sulfonamido group, an aryl group, an alkylthio group, an alkylamino group, an alkoxycarbonyl group, an acyloxy group, an alkylsulfonyl group, an alkylsulfoxyl group, an alkylcarbamoyl group, an alkylsulfamoyl group, a formyl group, an acyl group, a silyl group, or a sulfoalkoxy group;    L₂ represents a non-free-radically polymerizable monodentate or polydentate ligand;    X represents nitrogen or a methine group;    M is a divalent or polyvalent transition metal ion where the coordination number is at least four, and    k, m, and n are whole numbers less than or equal to 3. Dye-donor sheets comprising the abovementioned dyes are also disclosed.

  本发明提供了在有机介质中具有优异溶解性的金属偶氮染料。本发明的含金属染料具有如下式的核： 其中 Z₁ 和 Z₂ 各自独立地代表具有 5 至 14 个环原子的炔核； G₁ 和 G₂ 各自独立地代表金属连接基团，其中 G₁ 和 G₂ 可包含在 Z₁ 和 Z₂ 中的至少一个内或悬挂在其中的至少一个上； R 代表氢原子、卤素原子、烷基、酰氨基、烷氧基、磺酰胺基、芳基、硫醇基、 烷硫基、芳硫基、烷基氨基、芳基氨基、氨基、烷氧羰基、酰氧基、硝基氰基、烷基磺酰基、芳基磺酰基、烷基砜酰基、芳基砜酰基、芳氧基、羟基、硫胺基、氨基甲酰基、氨基磺酰基、甲酰基、酰基、脲基、芳氧羰基、硅烷基或磺酰烷氧基； L₁ 代表三烷基或三芳基膦配体；或 L₁ 代表不含可自由基聚合官能团的吡啶环基，且在 2-位和 6-位上不含取代基，吡啶环基的 3-位、4-位和 5-位中至少有一个被 R₁ 取代，其中； R₁ 代表烷基、酰氨基、烷氧基、磺酰胺基、芳基、烷硫基、烷氨基、烷氧羰基、酰氧基、烷基磺酰基、烷基硫氧酰基、烷基氨基甲酰基、烷基氨基磺酰基、甲酰基、酰基、硅烷基或磺基烷氧基； L₂ 代表非自由基聚合的单齿或多齿配体； X 代表氮或甲基； M 是配位数至少为 4 的二价或多价过渡金属离子，且 k、m 和 n 是小于或等于 3 的整数。 此外，还公开了包含上述染料的染料载体片。
• US5314998A
  申请人：——

  公开号：US5314998A

  公开（公告）日：1994-05-24
• US5461155A
  申请人：——

  公开号：US5461155A

  公开（公告）日：1995-10-24
• Cleavage of 4-Nitrophenyl Diphenyl Phosphate by Isomeric Quaternary Pyridinium Ketoximes - How Can Structure and Lipophilicity of Functional Surfactants Influence Their Reactivity in Micelles and Microemulsions?
  作者：Milan Kivala、Radek Cibulka、František Hampl

  DOI：10.1135/cccc20061642

  日期：——

  Amphiphilic pyridinium ketoximes 4-[1-(hydroxyimino)alkyl]-1-methylpyridinium bromides (1) and 1-alkyl-4-[1-(hydroxyimino)ethyl]pyridinium bromides (2) are isomeric cationic surfactants bearing the nucleophilic hydroxyimino group. They differ in the position of the nucleophilic function relative to polar head group and hydrophobic alkyl chain. The 4-nitrophenyl diphenyl phosphate (PNPDPP) cleavage by the oximate anions generated from 1 and 2 was used as a model reaction for the investigation of the influence of the structure and lipophilicity of functional surfactants on their reactivity in micelles and microemulsions. The investigation of the model reaction in cationic micelles of hexadecyltrimethylammonium bromide (CTAB), in non-ionic micelles (Triton X-100 and Brij 35) and in o/w microemulsion (isooctane/phosphate buffer/CTAB and butan-1-ol) has revealed that it is the lipophilicity which is the most important factor influencing the localization and reactivity of functional surfactants in nanoaggregates.

  两种异构阳离子表面活性剂分别为4-[1-(羟亚胺)烷基]-1-甲基吡啶溴化物（1）和1-烷基-4-[1-(羟亚胺)乙基]吡啶溴化物（2），它们是含有亲核羟亚胺基团的两性分子。它们在亲核功能相对于极性头基团和疏水烷基链的位置上有所不同。通过从1和2生成的羟肟阴离子对4-硝基苯二苯磷酸三酯（PNPDPP）的裂解被用作模型反应，以研究功能性表面活性剂的结构和亲脂性对其在胶束和微乳中的反应性的影响。在正十六烷基三甲基溴化铵（CTAB）的阳离子胶束、非离子胶束（Triton X-100和Brij 35）以及o/w型微乳（异辛烷/磷酸缓冲液/CTAB和正丁醇）中对模型反应的研究表明，亲脂性是影响功能性表面活性剂在纳米聚集体中定位和反应性的最重要因素。
• Controlling chemoselective transformations of 4-acylpyridines via a Pd–C catalytic hydrodechlorination–hydrogenation
  作者：Chuanjie Cheng、Bo Wang、Nan Liu、Wenwen Chen、Xinyan Wang、Yuefei Hu

  DOI：10.1016/j.tet.2013.12.017

  日期：2014.1

  A novel Pd-C catalytic hydrodechlorination-hydrogenation was developed for a multi-step one-pot transformation of 4-acylpyridines. Under the selected conditions, 4-benzoylpyridines and 4-alkanoylpyridines were chemoselectively converted into the corresponding 4-benzylpiperidine hydrochlorides and alpha-alkyl-4-piperidinemethanol hydrochlorides, respectively. This catalytic method was performed simply by an addition of 1 equiv of CICH2CHCl2 to the conventional hydrogenation system and directly gave the crystalline piperidine hydrochlorides in practical quantitative yields. (C) 2013 Elsevier Ltd. All rights reserved.