N-[3-carbamoyl-5-(1-phenylethyl)-thien-2-yl]quinoline-8-carboxamide | 383380-96-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-[3-carbamoyl-5-(1-phenylethyl)-thien-2-yl]quinoline-8-carboxamide
• 英文别名: N-[3-carbamoyl-5-(1-phenylethyl)thiophen-2-yl]quinoline-8-carboxamide
• CAS: 383380-96-9
• 化学式: C₂₃H₁₉N₃O₂S
• 分子量: 401.489
• InChiKey: STHIQXDKWUHJHM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  113
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Quinoline containing compounds and their use for treating endoplasmic reticulum stress-related diseases
  申请人：Dahl Russell

  公开号：US10383868B2

  公开（公告）日：2019-08-20

  Provided herein are quinoline, pharmaceutical compositions thereof, and methods of their use for treating, preventing, or ameliorating one or more symptoms of an endoplasmic reticulum stress-caused disease. Also provided herein are methods of their use for reducing endoplasmic reticulum stress and modulating the activity of a sarcoplasmic/endoplasmic reticulum Ca2+ ATPase.

  本文提供了喹啉、其药物组合物及其用于治疗、预防或改善内质网应激引起的疾病的一种或多种症状的方法。本文还提供了它们用于降低内质网应激和调节肌浆/内质网 Ca2+ ATP 酶活性的方法。
• QUINOLINE CONTAINING COMPOUNDS AND THEIR USE FOR TREATING ENDOPLASMIC RETICULUM STRESS-RELATED DISEASES
  申请人：Dahl Russell

  公开号：US20170231973A1

  公开（公告）日：2017-08-17

  Provided herein are quinoline, pharmaceutical compositions thereof, and methods of their use for treating, preventing, or ameliorating one or more symptoms of an endoplasmic reticulum stress-caused disease. Also provided herein are methods of their use for reducing endoplasmic reticulum stress and modulating the activity of a sarcoplasmic/endoplasmic reticulum Ca 2+ ATPase.
• US6414013B1
  申请人：——

  公开号：US6414013B1

  公开（公告）日：2002-07-02