8-iodo-1-methyl-5,6,7,8-tetrahydro-1-quinolinium iodide | 115607-39-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 8-iodo-1-methyl-5,6,7,8-tetrahydro-1-quinolinium iodide
• 英文别名: 8-iodo-1-methyl-5,6,7,8-tetrahydroquinolin-1-ium;iodide
• CAS: 115607-39-1
• 化学式: C₁₀H₁₃IN*I
• 分子量: 401.029
• InChiKey: RUZWXWIPOQAJGM-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -0.67
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  3.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  8-iodo-1-methyl-5,6,7,8-tetrahydro-1-quinolinium iodide 生成 1-methyl-8-(methylamino)-5,6,7,8-tetrahydro-1-quinolinium iodide
  参考文献：
  名称：

  CLEMENCE, FRANCOIS; LE MARTRET, ODILE; DELEVALLEE, FRANCOISE; FORTIN, MIC+

  摘要：

  DOI：
• 作为产物：
  描述：

  8-氯-5,6,7,8-四氢喹啉 生成 8-iodo-1-methyl-5,6,7,8-tetrahydro-1-quinolinium iodide
  参考文献：
  名称：

  CLEMENCE, FRANCOIS; LE MARTRET, ODILE; DELEVALLEE, FRANCOISE; FORTIN, MIC+

  摘要：

  DOI：

文献信息

• Decahydroquinolines and central analgesic method of use thereof
  申请人：Roussel Uclaf

  公开号：US04877796A1

  公开（公告）日：1989-10-31

  A compound selected from the group consisting of all enantiomeric and diastereoisomeric forms of a decahydroquinoline of the formula ##STR1## wherein R.sub.1 is alkyl of 1 to 5 carbon atoms, R.sub.2 is selected from the group consisting of hydrogen and akyl of 1 to 5 carbon atoms, A is selected from the group consisting of --(CH.sub.2).sub.n --, --CH.sub.2 O-- and alkylene substituted with alkyl having a total of 2 to 8 carbon atoms, n is an integer from 0 to 5, Z is selected from the group consisting of optionally substituted phenyl, optionally substituted naphthyl, optionally substituted indenyl, optionally substituted heteromonocycle of 5 to 6 members and optionally substituted heterobicycle with the proviso that when Z is o-alkoxy-phenyl, A is not --(CH.sub.2).sub.n -- in which n is O, and their non-toxic, pharmaceutically acceptable acid addition salts and their quaternary ammonium salts and intermediates having analgesic, diuretic, hypotensive, anti-arrithmic and anti-cerebral-ischaemic properties.

  从包括所有十氢喹啉的对映体和非对映异构体中选择的化合物，其化学式为##STR1##其中R.sub.1是1到5个碳原子的烷基，R.sub.2选自氢和1到5个碳原子的烷基，A选自--(CH.sub.2).sub.n --，--CH.sub.2 O--和取代有总共2到8个碳原子的烷基的烷基取代的烷基，n是0到5的整数，Z选自可选取代的苯基，可选取代的萘基，可选取代的茚基，可选取代的5到6成员的杂单环和可选取代的杂环并环，条件是当Z是o-烷氧基苯基时，A不是n为0的--(CH.sub.2).sub.n --，以及其无毒、药学上可接受的酸加盐和季铵盐以及具有镇痛、利尿、降压、抗心律失常和抗脑缺血性的性质的中间体。
• Decahydroquinolines and 5,6,7,8 tetrahydroquinolines
  申请人：Roussel Uclaf

  公开号：US04950760A1

  公开（公告）日：1990-08-21

  A compound selected from the group consisting of all enantiomeric and diastereoisomeric forms of a decahydroquinoline of the formula ##STR1## wherein R.sub.1 is alkyl of 1 to 5 carbon atoms, R.sub.2 is selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms, A is selected from the group consisting of --(CH.sub.2).sub.n --, --CH.sub.2 O-- and alkylene substituted with alkyl having a total of 2 to 8 carbon atoms, n is an integer from 0 to 5, Z is selected from the group consisting of optionally substituted phenyl, optionally substituted naphthyl, optionally substituted indenyl, optionally substituted heteromonocycle of 5 to 6 members and optionally substituted heterobicycle with the proviso that when Z is o-alkoxy-phenyl, A is not --(CH.sub.2).sub.n -- in which n is O, and their non-toxic, pharmaceutically acceptable acid addition salts and their quaternary ammonium salts and intermediates having analgesic, diuretic, hypotensive, anti-arrithmic and anti-cerebral-ischaemic properties.

  从所有的十氢喹啉的对映体和非对映异构体中选择一种化合物，其化学式为##STR1##其中R.sub.1为1至5个碳原子的烷基，R.sub.2选自氢和1至5个碳原子的烷基，A选自--(CH.sub.2).sub.n --、--CH.sub.2 O--和取代有总共2至8个碳原子的烷基的烷基取代的亚烷基，n是0至5的整数，Z选自可选择取代的苯基、可选择取代的萘基、可选择取代的茚基、5至6个成员的可选择取代的杂环和可选择取代的杂环，但当Z为o-烷氧基苯基时，A不是n为0的--(CH.sub.2).sub.n --，其非毒性、药学上可接受的酸盐和其季铵盐以及具有镇痛、利尿、降压、抗心律失常和抗脑缺血的中间体。
• 8-amino decahydroquinolines and medicinal use thereof
  申请人：Roussel Uclaf

  公开号：US04963567A1

  公开（公告）日：1990-10-16

  A compound selected from the group consisting of all enantiomeric and diastereoisomeric forms of a decahydroquinoline of the formula ##STR1## wherein R.sub.1 is alkyl of 1 to 5 carbon atoms, R.sub.2 is selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms, A is selected from the group consisting of --(CH.sub.2).sub.n --, --CH.sub.2 O-- and alkylene substituted with alkyl having a total of 2 to 8 carbon atoms, n is an integer from 0 to 5, Z is selected from the group consisting of optionally substituted phenyl, optionally substituted naphthyl, optionally substituted indenyl, optionally substituted heteromonocycle of 5 to 6 members and optionally substituted hetero-bicycle with the proviso that when Z is o-alkoxy-phenyl, A is not --(CH.sub.2).sub.n -- in which n is O, and their non-toxic, pharmaceutically acceptable acid addition salts and their quaternary ammonium salts and intermediates having analgesic, diuretic, hypotensive, anti-arrithmic and anti-cerebral-ischaemic properties.

  从所有的右旋和左旋异构体中选择的一种化合物，其化学式为##STR1##其中R.sub.1是1到5个碳原子的烷基，R.sub.2选自氢和1到5个碳原子的烷基，A选自--（CH.sub.2）.sub.n --，--CH.sub.2 O--和被取代的烷基取代的含有2到8个碳原子的烷基，n是0到5的整数，Z选自可选取代的苯基，可选取代的萘基，可选取代的茚基，含有5到6个成员的可选取代的杂环和可选取代的杂环并环，但当Z为o-烷氧基苯基时，A不是在其中n为0的--（CH.sub.2）.sub.n --，以及它们的非毒性、药学上可接受的酸盐和其季铵盐以及具有镇痛、利尿、降压、抗心律失常和抗脑缺血作用的中间体。
• CLEMENCE, FRANCOIS;MARTRET, ODILE LE;DELEVALLEE, FRANCOISE;FORTIN, MICHEL
  作者：CLEMENCE, FRANCOIS、MARTRET, ODILE LE、DELEVALLEE, FRANCOISE、FORTIN, MICHEL

  DOI：——

  日期：——
• US4877796A
  申请人：——

  公开号：US4877796A

  公开（公告）日：1989-10-31