6-iodo-8-quinolinol | 497084-49-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-iodo-8-quinolinol
• 英文别名: 6-Iodoquinolin-8-ol
• CAS: 497084-49-8
• 化学式: C₉H₆INO
• 分子量: 271.057
• InChiKey: WTJPFVGYUOUGCQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  33.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  6-碘-2(3H-)-苯并噁唑酮 、 甘油 在 arsenic(V) oxide 、 硫酸 作用下， 反应 2.0h， 以2.8%的产率得到6-iodo-8-quinolinol
  参考文献：
  名称：

  Preparation and Antifungal Activity of 3-Iodo- and 6-Iodo-8-quinolinols

  摘要：

  3-Iodo- and 6-Iodo-8-quinolinols were prepared and tested against six fungi: Aspergillus niger, A. oryzae, Myrothecium verrucaria, Trichoderma viride, Mucor cirinelloides, and Trichopkyton mentagrophytes in Sabouraud dextrose broth. A comparison with the previously known 5-iodo- and 7-iodo-8-quinolinols showed that the 6-iodo isomer was the most active.

  DOI：

  10.1007/s00706-002-0495-6

文献信息

• Quinoline Derivatives for Diagnosis and Treatment of Alzheimer's Disease
  申请人：Northeastern University

  公开号：US20180141911A1

  公开（公告）日：2018-05-24

  A new class of quinoline compounds is useful for the detection and treatment of Alzheimer's disease and other neurodegenerative diseases such as amyloidoses and tauopathies. The compounds can be synthesized in radiolabeled form for use as imaging agents, which can be used for early detection of aggregates in the brain or other tissues prior to onset of symptoms, allowing early therapeutic intervention. The compounds are also useful for the prevention and treatment of such diseases.