1-(methoxymethyl)-3-[(E)-2-nitroethenyl]indole | 733747-57-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-(methoxymethyl)-3-[(E)-2-nitroethenyl]indole
• CAS: 733747-57-4
• 化学式: C₁₂H₁₂N₂O₃
• 分子量: 232.239
• InChiKey: XLFABXKPRHKXAB-VOTSOKGWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  60
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(methoxymethyl)-3-[(E)-2-nitroethenyl]indole 在 正丁基锂 、 盐酸羟胺 、 sodium acetate 作用下， 以 四氢呋喃 、 甲醇 、 正戊烷 为溶剂， 生成
  参考文献：
  名称：

  Efficient one-pot synthesis of anti HIV and antitumor compounds: harman and substituted harmans

  摘要：

  Anti HIV and antitumor compounds, harman and substituted harmans have been synthesized using electrocyclization reactions as key steps. A one-pot reaction sequence was used to furnish these compounds in good overall yield. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(03)01046-3
• 作为产物：
  描述：

  硝基甲烷 、 1-(methoxymethyl)-1H-indole-3-carbaldehyde 在 sodium acetate 作用下， 以 溶剂黄146 为溶剂， 以50%的产率得到1-(methoxymethyl)-3-[(E)-2-nitroethenyl]indole
  参考文献：
  名称：

  Efficient one-pot synthesis of anti HIV and antitumor compounds: harman and substituted harmans

  摘要：

  Anti HIV and antitumor compounds, harman and substituted harmans have been synthesized using electrocyclization reactions as key steps. A one-pot reaction sequence was used to furnish these compounds in good overall yield. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(03)01046-3

文献信息

• Efficient one-pot synthesis of anti HIV and antitumor compounds: harman and substituted harmans
  作者：Radhika S. Kusurkar、Shailesh K. Goswami、Sandhya M. Vyas

  DOI：10.1016/s0040-4039(03)01046-3

  日期：2003.6

  Anti HIV and antitumor compounds, harman and substituted harmans have been synthesized using electrocyclization reactions as key steps. A one-pot reaction sequence was used to furnish these compounds in good overall yield. (C) 2003 Elsevier Science Ltd. All rights reserved.
• Efficient one-pot synthesis of anti-HIV and anti-tumour β-carbolines
  作者：Radhika S Kusurkar、Shailesh K Goswami

  DOI：10.1016/j.tet.2004.04.079

  日期：2004.6

  Thermal electrocyclisation of the azahexatriene system has been used as a key step for the synthesis of anti-HIV and anti-tumour compounds, harman, derivatives of harman and 1-aryl-beta-carbolines. A one-pot reaction sequence was used to furnish these compounds in good yield. (C) 2004 Elsevier Ltd. All rights reserved.