(2R,3R,4S,5R,6R)-2-(4-amino-3-tritiophenoxy)-6-(hydroxymethyl)oxane-3,4,5-triol | 261964-27-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2R,3R,4S,5R,6R)-2-(4-amino-3-tritiophenoxy)-6-(hydroxymethyl)oxane-3,4,5-triol
• CAS: 261964-27-6
• 化学式: C₁₂H₁₇NO₆
• 分子量: 273.262
• InChiKey: MIAKOEWBCMPCQR-BTTULOJASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  125
• 氢给体数：
  5
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  (2R,3R,4S,5R,6R)-2-(4-amino-3-tritiophenoxy)-6-(hydroxymethyl)oxane-3,4,5-triol 在 三氟乙酸 、 sodium nitrite 、 sodium azide 作用下， 反应 2.5h， 生成 (2R,3R,4S,5R,6R)-2-(4-azido-3-tritiophenoxy)-6-(hydroxymethyl)oxane-3,4,5-triol
  参考文献：
  名称：

  Syntheses and properties of photoactivatable sugar derivatives designed to probe the sugar-binding site of melibiose permease

  摘要：

  Three new photoreactive sugar analogues bearing an azido, a diazonium salt or a diazirine group as the photophore as well as a tritium atom were developed. Two of these new photoactivatable compounds gave excellent preliminary results, with a high affinity for the melibiose permease of Escherichia coli. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00180-3
• 作为产物：
  描述：

  4-aminophenyl α-D-galactopyranoside 在 超重氢 、 溴 、 溶剂黄146 、 三乙胺 作用下， 以 甲醇 、 水 为溶剂， 20.0 ℃ 、101.33 kPa 条件下， 反应 4.0h， 生成 (2R,3R,4S,5R,6R)-2-(4-amino-3-tritiophenoxy)-6-(hydroxymethyl)oxane-3,4,5-triol
  参考文献：
  名称：

  Syntheses and properties of photoactivatable sugar derivatives designed to probe the sugar-binding site of melibiose permease

  摘要：

  Three new photoreactive sugar analogues bearing an azido, a diazonium salt or a diazirine group as the photophore as well as a tritium atom were developed. Two of these new photoactivatable compounds gave excellent preliminary results, with a high affinity for the melibiose permease of Escherichia coli. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00180-3

文献信息

• Syntheses and properties of photoactivatable sugar derivatives designed to probe the sugar-binding site of melibiose permease
  作者：Yves Ambroise、Charles Mioskowski、Gérard Leblanc、Bernard Rousseau

  DOI：10.1016/s0960-894x(00)00180-3

  日期：2000.5

  Three new photoreactive sugar analogues bearing an azido, a diazonium salt or a diazirine group as the photophore as well as a tritium atom were developed. Two of these new photoactivatable compounds gave excellent preliminary results, with a high affinity for the melibiose permease of Escherichia coli. (C) 2000 Elsevier Science Ltd. All rights reserved.