4-Chloro-3,3,4,4-tetrafluorobutanal | 131118-28-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-Chloro-3,3,4,4-tetrafluorobutanal
• CAS: 131118-28-0
• 化学式: C₄H₃ClF₄O
• 分子量: 178.514
• InChiKey: WXCUSEKTKJXMRQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-硝基苯胺 、 4-Chloro-3,3,4,4-tetrafluorobutanal 以 水 、 乙腈 为溶剂， 反应 2.0h， 以83%的产率得到(Z)-4-[(4-nitrophenyl)amino]-1,1-difluoro-1-chloro-3-buten-2-one
  参考文献：
  名称：

  Reactions of 2,2-dihydropolyfluoroalkylaldehydes with amines: a facile synthetic method for fluoroalkyl enaminoketones

  摘要：

  Reactions of 2,2-dihydropolyfluoroalkylaldehydes (1) with amines (2) were studied. Both aliphatic amines and electron-deficient aromatic amines readily reacted with I in acetonitrile and water under reflux to give fluoroalkyl enaminoketones (3) in high yields, while no condensed products were obtained by reactions of 1 with electron-rich aromatic amines under similar conditions. In the presence of triethylamine, however, the reaction of 1 with electron-rich aromatic amines at room temperature gave 3 in low yields. (C) 2003 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2003.11.005
• 作为产物：
  描述：

  1-氯-2-碘四氟乙烷, 、 乙烯基乙醚 在 sodium dithionite 作用下， 以 水 、 乙腈 为溶剂， 生成 4-Chloro-3,3,4,4-tetrafluorobutanal
  参考文献：
  名称：

  Synthesis of 5-per(poly)fluoroalkyl-2,3-dihydro-1,4-diazepines

  摘要：

  a series of 5-per(poly)fluoroalkyl-2,3-dihydro-1,4-diazepines were synthesized from alpha-per(poly)fluoroalkyl aldehydes and ethylenediamine. A possible reaction pathway was suggested. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)00261-5

文献信息

• A Novel Synthesis of 2-Fluoroalkyl Quinolines
  作者：Quan-Fu Wang、Yun-Yu Mao、Chao-Yue Qin、Shi-Zheng Zhu、Chang-Ming Hu

  DOI：10.1007/s007060050006

  日期：2000.1.15

  2-Fluoroalkyl quinolines are prepared by reacting aniline with alpha-fluoroalkyl aldehydes or alpha-fluoroalkyl cyclohexanones in the presence of acetic acid. Under the same reaction condition, 2-aminophenol gives the corresponding 2-fluoroalkyl-8-quinolinols; in some cases, 2-fluoroalkyl benzoxazoles are also formed as minor products.
• A novel synthesis of 2-per(poly)fluoroalkyl-1H-benzimidazoles or 2-per(poly) fluoroalkyl benzothiazoles
  作者：Quan-Fu Wang、Yun-Yu Mao、Shi-Zheng Zhu、Chang-Ming Hu

  DOI：10.1016/s0022-1139(99)00012-3

  日期：1999.6

  A new method for the preparation of 2-per(poly)fluoroalkyl-1H-benzimidazoles or 2-per(poly)fluoroalkyl benzothiazoles from reaction of readily available alpha-per(poly)fluoroalkyl aldehydes with o-phenylenediamine or 2-aminobenzenethiol is presented. A possible reaction pathway is suggested. (C) 1999 Elsevier Science S.A. All rights reserved.
• Synthesis of 5-per(poly)fluoroalkyl-2,3-dihydro-1,4-diazepines
  作者：Quan-Fu Wang、Bin Hu、Bing-Hao Luo、Chang-Ming Hu

  DOI：10.1016/s0040-4039(98)00261-5

  日期：1998.4

  a series of 5-per(poly)fluoroalkyl-2,3-dihydro-1,4-diazepines were synthesized from alpha-per(poly)fluoroalkyl aldehydes and ethylenediamine. A possible reaction pathway was suggested. (C) 1998 Elsevier Science Ltd. All rights reserved.
• Reactions of 2,2-dihydropolyfluoroalkylaldehydes with amines: a facile synthetic method for fluoroalkyl enaminoketones
  作者：Xian-Jin Yang、Jin-Tao Liu、Fu-Lu Zhao

  DOI：10.1016/j.jfluchem.2003.11.005

  日期：2004.3

  Reactions of 2,2-dihydropolyfluoroalkylaldehydes (1) with amines (2) were studied. Both aliphatic amines and electron-deficient aromatic amines readily reacted with I in acetonitrile and water under reflux to give fluoroalkyl enaminoketones (3) in high yields, while no condensed products were obtained by reactions of 1 with electron-rich aromatic amines under similar conditions. In the presence of triethylamine, however, the reaction of 1 with electron-rich aromatic amines at room temperature gave 3 in low yields. (C) 2003 Elsevier B.V. All rights reserved.