2'',2'''-di-O-benzoyl-4'',6''-O-cyclohexylidene-3,2',6',3'',4'''-pentakis(N-tert-butoxucarbonyl)arbekacin | 189157-33-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2'',2'''-di-O-benzoyl-4'',6''-O-cyclohexylidene-3,2',6',3'',4'''-pentakis(N-tert-butoxucarbonyl)arbekacin
• CAS: 189157-33-3
• 化学式: C₆₇H₁₀₀N₆O₂₂
• 分子量: 1341.56
• InChiKey: WBBNDBUTZXNLEC-LGMQVSPJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.88
• 重原子数：
  95.0
• 可旋转键数：
  18.0
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  348.96
• 氢给体数：
  7.0
• 氢受体数：
  22.0

反应信息

• 作为反应物：
  描述：

  2'',2'''-di-O-benzoyl-4'',6''-O-cyclohexylidene-3,2',6',3'',4'''-pentakis(N-tert-butoxucarbonyl)arbekacin 在 4,4'-二氨基二苯乙烯-2,2'-二磺酸 作用下， 以 二氯甲烷 为溶剂， 反应 6.0h， 以71%的产率得到2'',2'''-di-O-benzoyl-4'',6''-O-cyclohexylidene-5-deoxy-5-epi-5-fluoro-3,2',6',3'',4'''-pentakis(N-tert-butoxucarbonyl)arbekacin
  参考文献：
  名称：

  Synthesis of 2″-oxidized derivatives of 5-deoxy-5-epi-5-fluoro-dibekacin and -arbekacin, and study on structure-chemical shift relationships of urethane(or amide)-type NH protons in synthetic intermediates

  摘要：

  Three 2''-modified dibekacin-analogs have been prepared as potential compounds active against resistant bacteria producing 2''-O-phosphotransferases; one is 5-deoxy-5,2''-diepi-5-fluorodibekacin (9) prepared from a suitably protected 2''-O-triflyl derivative through the 2'',3''-cyclic carbamate, and the others are 2''-oxo derivatives (12 and 22, both as the hydrate) of 5-deoxy-5-epi-5-fluoro-dibekacin and -arbekacin prepared through oxidation at C-2'' of suitably protected derivatives. Relationships between the t-butoxycarbonyl(= Boc)-NH-shifts of per-N-Boc synthetic intermediates and their structures were studied. It was found that the shifts, measured in pyridine-d(5) at 80 degrees C, which spread over a close range (delta 6-7 ppm), are sensitively influenced by nearby and surrounding groups around the BocNH group in respect of electron-withdrawing character, hydrogen bonding (BocNH ... acceptor), and also solvent effects (BocNH ... NC5H5). (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0008-6215(96)00318-7
• 作为产物：
  描述：

  环己酮二甲缩酮 在 吡啶 、 对甲苯磺酸 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 25.0~50.0 ℃ 、4.0 kPa 条件下， 反应 4.0h， 生成 2'',2'''-di-O-benzoyl-4'',6''-O-cyclohexylidene-3,2',6',3'',4'''-pentakis(N-tert-butoxucarbonyl)arbekacin
  参考文献：
  名称：

  Synthesis of 2″-oxidized derivatives of 5-deoxy-5-epi-5-fluoro-dibekacin and -arbekacin, and study on structure-chemical shift relationships of urethane(or amide)-type NH protons in synthetic intermediates

  摘要：

  Three 2''-modified dibekacin-analogs have been prepared as potential compounds active against resistant bacteria producing 2''-O-phosphotransferases; one is 5-deoxy-5,2''-diepi-5-fluorodibekacin (9) prepared from a suitably protected 2''-O-triflyl derivative through the 2'',3''-cyclic carbamate, and the others are 2''-oxo derivatives (12 and 22, both as the hydrate) of 5-deoxy-5-epi-5-fluoro-dibekacin and -arbekacin prepared through oxidation at C-2'' of suitably protected derivatives. Relationships between the t-butoxycarbonyl(= Boc)-NH-shifts of per-N-Boc synthetic intermediates and their structures were studied. It was found that the shifts, measured in pyridine-d(5) at 80 degrees C, which spread over a close range (delta 6-7 ppm), are sensitively influenced by nearby and surrounding groups around the BocNH group in respect of electron-withdrawing character, hydrogen bonding (BocNH ... acceptor), and also solvent effects (BocNH ... NC5H5). (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0008-6215(96)00318-7

文献信息

• EP1710248
  申请人：——

  公开号：——

  公开（公告）日：——