(+/-)-1-hydroxy-2t-phenyl-cyclohexane-carbonitrile-(1r) | 61875-85-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (+/-)-1-hydroxy-2t-phenyl-cyclohexane-carbonitrile-(1r)
• 英文别名: (+/-)-1-Hydroxy-2t-phenyl-cyclohexan-carbonitril-(1r)；(1R,2R)-1-hydroxy-2-phenylcyclohexane-1-carbonitrile
• CAS: 61875-85-2
• 化学式: C₁₃H₁₅NO
• 分子量: 201.268
• InChiKey: QIBMDZSPTGWYAU-OLZOCXBDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  44
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  吡啶 、 氯化亚砜 、 (+/-)-1-hydroxy-2t-phenyl-cyclohexane-carbonitrile-(1r) 生成 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  The Angular Aryl Group. II. N-Methyl-10-phenyldecahydroisoquinoline

  摘要：

  DOI：

  10.1021/ja01158a016
• 作为产物：
  描述：

  1-苯-1,3-丁二烯 在 氧气 、 对苯二酚 、 tin(ll) chloride 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 为溶剂， 反应 73.0h， 生成 (+/-)-1-hydroxy-2t-phenyl-cyclohexane-carbonitrile-(1r)
  参考文献：
  名称：

  Oxidative decyanation of secondary nitriles to ketones

  摘要：

  DOI：

  10.1021/jo00170a043

文献信息

• Goldschmidt; Veer, Recueil des Travaux Chimiques des Pays-Bas, 1948, vol. 67, p. 489,506
  作者：Goldschmidt、Veer

  DOI：——

  日期：——
• Ring Enlargements. I. The Ring Enlargement of 2-Chlorocyclohexanone and 2-Phenylcyclohexanone
  作者：C. David. Gutsche

  DOI：10.1021/ja01178a075

  日期：1949.10
• Sigmoid and transverse sinus thrombosis after closed head injury presenting with unilateral hearing loss
  作者：D. Brors、M. Schäfers、B. Schick、S. Dazert、W. Draf、G. Kahle

  DOI：10.1007/pl00006045

  日期：2001.2.5

  Sinus thrombosis has rarely been associated with closed head injury; more often, thrombosis of the sigmoid or transverse sinus is caused by otogenic inflammations or tumours, or occurs during pregnancy. Symptoms are frequently vague, while untreated thrombus progression may be fatal due to venous congestion and infarction. We report a 32-year-old man presenting with right hearing loss, tinnitus and headache 2 days after a closed head injury. Neurological examination showed no additional abnormality. The EEG showed focal bifrontal slowing. CT revealed a fracture of the occipital bone. MRI and MRA demonstrated complete thrombosis of the right sigmoid and transverse sinuses. After 2 weeks of intravenous heparin therapy followed by warfarin, the patient's hearing improved and MRI and MRA showed complete recanalisation of the sigmoid and transverse sinuses. Venous sinus thrombosis can be an undetected sequel to head injury. Appropriate imaging studies should be carried out to enable therapy to be started as soon as possible.
• The Dehydration of 2-Phenylcyclohexanone Cyanohydrin: 6-Phenyl-Δ¹-cyclohexenecarbonitrile and 2-Phenyl-Δ¹-cyclohexenecarbonitrile
  作者：WILLIAM E. PARHAM、WILBUR N. MOULTON、ALEXANDER ZUCKERBRAUN

  DOI：10.1021/jo01107a013

  日期：1956.1