| 1295299-04-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子
• CAS: 1295299-04-5
• 化学式: C₄₀H₅₄N₆O₈
• 分子量: 746.904
• InChiKey: MTHRRNHVEQQUNO-LDGBVSBFSA-N

反应信息

• 作为产物：
  描述：

  N-methyl-leucine azidoacetamide 、 在 2,6-二甲基吡啶 、 N-羟基-7-氮杂苯并三氮唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 16.0h， 生成
  参考文献：
  名称：

  Sugar amino acid based peptide epoxyketones as potential proteasome inhibitors

  摘要：

  This paper describes the synthesis and biological evaluation of nine epoxomicin-derived sugar amino acid containing peptide epoxyketones. The title compounds are assembled from six sugar amino acid dipeptide isosteres and are synthesized using solution-phase peptide synthesis protocols. Although neither of the compounds displays inhibitory activity towards any of the proteasome active sites, our approach holds promise towards the development of structurally new proteasome inhibitors. It is likely that the central sugar amino acid dipeptide isoster needs to be designed such that it closely resemble dipeptides at position P2 and P3 in proteasome substrates inhibitors, such as the Thr-Ile dipeptide present in the lead compound, epoxomicin. (C) 2010 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.bioorg.2010.04.004