ethyl 1-(4-acetoxybutyl)-6-(2,4-dichlorobenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylate | 1048998-74-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: ethyl 1-(4-acetoxybutyl)-6-(2,4-dichlorobenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylate
• CAS: 1048998-74-8
• 化学式: C₂₅H₂₅Cl₂NO₅
• 分子量: 490.383
• InChiKey: CQJMXHPYCOBRPQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.42
• 重原子数：
  33.0
• 可旋转键数：
  9.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  74.6
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  ethyl 1-(4-acetoxybutyl)-6-(2,4-dichlorobenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylate 在 sodium hydroxide 、 水 、 盐酸 作用下， 以 水 为溶剂， 反应 2.0h， 以75%的产率得到6-(2,4-二氯苄基)-1-(4-羟基丁基)-4-氧代-1,4-二氢喹啉-3-羧酸
  参考文献：
  名称：

  Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 1. Synthesis and Structure−Activity Relationship of a Class of Human Immunodeficiency Virus type 1 Integrase Inhibitors

  摘要：

  A set of 4-quinolone-3-carboxylic acids bearing different substituents on the condensed benzene ring was designed and synthesized as potential HIV-1 integrase inhibitors structurally related to elvitegravir. Some of the new compounds proved to be able to inhibit the strand transfer step of the virus integration process in the micromolar range. Docking studies and quantum mechanics calculations were used to rationalize these data.

  DOI：

  10.1021/jm8003784
• 作为产物：
  描述：

  乙酸 4-碘丁酯 、 6-(2,4-二氯苄基)-4-氧代-1,4-二氢喹啉-3-羧酸乙酯 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 12.0h， 以60%的产率得到ethyl 1-(4-acetoxybutyl)-6-(2,4-dichlorobenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylate
  参考文献：
  名称：

  Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 1. Synthesis and Structure−Activity Relationship of a Class of Human Immunodeficiency Virus type 1 Integrase Inhibitors

  摘要：

  A set of 4-quinolone-3-carboxylic acids bearing different substituents on the condensed benzene ring was designed and synthesized as potential HIV-1 integrase inhibitors structurally related to elvitegravir. Some of the new compounds proved to be able to inhibit the strand transfer step of the virus integration process in the micromolar range. Docking studies and quantum mechanics calculations were used to rationalize these data.

  DOI：

  10.1021/jm8003784