4-(7-iodoquinolin-4-ylamino)-2-diethylaminomethylphenol | 83196-61-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-(7-iodoquinolin-4-ylamino)-2-diethylaminomethylphenol
• 英文别名: 2-(Diethylaminomethyl)-4-[(7-iodoquinolin-4-yl)amino]phenol
• CAS: 83196-61-6
• 化学式: C₂₀H₂₂IN₃O
• 分子量: 447.319
• InChiKey: LIFIXEDAQAQTEK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  48.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-乙酰胺-2-二乙氨甲基苯酚 在 盐酸 作用下， 生成 4-(7-iodoquinolin-4-ylamino)-2-diethylaminomethylphenol
  参考文献：
  名称：

  Heterocyclic Basic Compounds. XII. 7-Bromo-and 7-Iodo-quinolines

  摘要：

  DOI：

  10.1021/ja01177a504

文献信息

• [EN] NOVEL AMODIAQUINE ANALOGS AND METHODS OF USES THEREOF<br/>[FR] NOUVEAUX ANALOGUES D'AMODIAQUINE ET LEURS PROCÉDÉS D'UTILISATION
  申请人：TEXAS BIOMEDICAL RES INSTITUTE

  公开号：WO2018191642A1

  公开（公告）日：2018-10-18

  Described herein are pharmaceutical compositions capable of blocking entry of a virus into a host cell and containing one or more compounds of the general formula I or a pharmaceutically acceptable derivative thereof and methods of treatment or prophylactic administration of these pharmaceutical compositions to treat viral infections.

  本文描述了一种能够阻止病毒进入宿主细胞的药物组合物，其中包含一种或多种通用式I的化合物或其药用可接受的衍生物，并提供了使用这些药物组合物进行治疗或预防的方法，以治疗病毒感染。
• Antiviral drug for severe fever with thrombocytopenia syndrome
  申请人：Kagoshima University

  公开号：US11001557B2

  公开（公告）日：2021-05-11

  The present invention pertains to an antiviral drug for severe fever with thrombocytopenia syndrome, which contains a compound represented by formula (I) or a salt thereof, or a solvate of the compound or salt (In the formula, R1 and R2 are the same or different from each other, and each represents a substituted or unsubstituted C1-10 alkyl group, R1 and R2 may form a substituted or unsubstituted 5- or 6-member ring in conjunction with an adjacent nitrogen atom, and X represent a halogen atom.)

  本发明涉及一种治疗严重发热伴血小板减少综合征的抗病毒药物，它含有由式（I）代表的化合物或其盐，或该化合物或盐的溶液（式中，R1和R2彼此相同或不同，各自代表取代或未取代的C1-10烷基，R1和R2可与相邻的氮原子结合形成取代或未取代的5或6元环，X代表卤素原子）。
• ANTIVIRAL DRUG FOR SEVERE FEVER WITH THROMBOCYTOPENIA SYNDROME
  申请人：Kagoshima University

  公开号：EP3572081B1

  公开（公告）日：2021-10-20
• NOVEL AMODIAQUINE ANALOGS AND METHODS OF USES THEREOF
  申请人：TEXAS BIOMEDICAL RESEARCH INSTITUTE

  公开号：US20200113891A1

  公开（公告）日：2020-04-16

  Described herein are pharmaceutical compositions capable of blocking entry of a virus into a host cell and containing one or more compounds of the general formula I or a pharmaceutically acceptable derivative thereof and methods of treatment or prophylactic administration of these pharmaceutical compositions to treat viral infections.