2-[4-[(4-ethyl-6-methoxy-2-methylquinolin-8-yl)amino]pentyl]isoindole-1,3-dione | 343810-40-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-[4-[(4-ethyl-6-methoxy-2-methylquinolin-8-yl)amino]pentyl]isoindole-1,3-dione
• CAS: 343810-40-2
• 化学式: C₂₆H₂₉N₃O₃
• 分子量: 431.535
• InChiKey: KQDCTNAJOBCVPM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.99
• 重原子数：
  32.0
• 可旋转键数：
  8.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  71.53
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  2-[4-[(4-ethyl-6-methoxy-2-methylquinolin-8-yl)amino]pentyl]isoindole-1,3-dione 在 肼 作用下， 以 乙醇 为溶剂， 反应 1.5h， 以78%的产率得到8-<(4'-amino-1'-methylbutyl)amino>-4-ethyl-6-methoxy-2-methylquinoline
  参考文献：
  名称：

  Synthesis of 2,4-disubstituted 6-methoxy-8-aminoquinoline analogs as potential antiparasitics

  摘要：

  A series of 2,4-disubstituted 8-aminoquinoline analogues were synthesized and evaluated against Plasmodium berghei in mice and Leishmania donovani in hamsters. 8-[[6-(Diethylamino)hexyl]amino]-2-ethyl-6-methoxy-4-methylquinoline (8a) possessed significant activity against L. donovani. 2-Ethyl-4-methylprimaquine (7a) was evaluated against Plasmodium cynomolgi in rhesus monkey and found to have activity equal to that of primaquine.

  DOI：

  10.1021/jm00179a023
• 作为产物：
  描述：

  4-ethyl-6-methoxy-2-methyl-8-nitroquinoline 在 盐酸 、 三乙胺 、 tin(ll) chloride 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 反应 6.0h， 生成 2-[4-[(4-ethyl-6-methoxy-2-methylquinolin-8-yl)amino]pentyl]isoindole-1,3-dione
  参考文献：
  名称：

  Synthesis of 2,4-disubstituted 6-methoxy-8-aminoquinoline analogs as potential antiparasitics

  摘要：

  A series of 2,4-disubstituted 8-aminoquinoline analogues were synthesized and evaluated against Plasmodium berghei in mice and Leishmania donovani in hamsters. 8-[[6-(Diethylamino)hexyl]amino]-2-ethyl-6-methoxy-4-methylquinoline (8a) possessed significant activity against L. donovani. 2-Ethyl-4-methylprimaquine (7a) was evaluated against Plasmodium cynomolgi in rhesus monkey and found to have activity equal to that of primaquine.

  DOI：

  10.1021/jm00179a023

文献信息

• CORROLLY F. I.; BERRANG B. D.; LINN C. P., J. MED. CHEM., 1980, 23, NO 5, 581-584
  作者：CORROLLY F. I.、 BERRANG B. D.、 LINN C. P.

  DOI：——

  日期：——