2-[(E)-(8-喹啉基亚肼基)甲基]-8-喹啉醇 | 24430-56-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 2-[(E)-(8-喹啉基亚肼基)甲基]-8-喹啉醇
• 英文名称: 3-Hydroxychinaldinaldehyd-8-chinolylhydrazon
• 英文别名: 2-Formyl-8-hydroxychinolin-8-chinolylhydrazon；8-Hydroxy-2-quinolinecarboxaldehyde 8-quinolylhydrazone；2-[(E)-(quinolin-8-ylhydrazinylidene)methyl]quinolin-8-ol
• CAS: 24430-56-6
• 化学式: C₁₉H₁₄N₄O
• 分子量: 314.346
• InChiKey: MVRYUWHNRSHURE-CIAFOILYSA-N

物化性质

• 熔点：
  205-210 °C

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  70.4
• 氢给体数：
  2
• 氢受体数：
  5

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S26,S36
• 危险类别码：
  R36/37/38
• 海关编码：
  2933499090

反应信息

• 作为产物：
  描述：

  8-羟基喹啉-2-甲醛 、 8-肼基喹啉盐酸盐 以97%的产率得到
  参考文献：
  名称：

  KRASAVIN I. A.; RADIN YU. P.; RYABOKOBYLKO YU. S.; PARUSNIKOV B. V.; DZIO+, XIMIYA GETEROTSIKL. SOEDIN., 1978, HO 2,

  摘要：

  DOI：

文献信息

• REMEDY FOR PRION DISEASE AND METHOD OF PRODUCING THE SAME
  申请人：Renomedix Institute Inc.

  公开号：EP1736162A1

  公开（公告）日：2006-12-27

  It is intended to provide a drug which is efficacious in treating a prion disease and has a high safety. A remedy for a prion disease which contains a mesenchymal stem cell as the active ingredient and a method of producing the same. A remedy for a prion disease which contains a mesenchymal stem cell, in particular, a mesenchymal stem cell having an anti-prion antibody gene transferred thereinto as the active ingredient and a method of producing the same. These remedies can not only prevent the progress of a prion disease but also contribute to the recovery of nerve dysfunction caused by the disease.

  其目的是提供一种对治疗朊病毒病有效且安全性高的药物。一种含有间充质干细胞作为活性成分的治疗朊病毒病的药物及其生产方法。一种治疗朊病毒病的药物，它含有间充质干细胞，特别是含有转入抗朊病毒抗体基因的间充质干细胞作为活性成分，以及生产这种药物的方法。这些疗法不仅可以防止朊病毒疾病的发展，还有助于恢复由该疾病引起的神经功能障碍。
• Remedy for prion disease and method of producing the same
  申请人：Fujinaga Kei

  公开号：US20070160585A1

  公开（公告）日：2007-07-12

  It is intended to provide a drug which is efficacious in treating a prion disease and has a high safety. A remedy for a prion disease which contains a mesenchymal stem cell as the active ingredient and a method of producing the same. A remedy for a prion disease which contains a mesenchymal stem cell, in particular, a mesenchymal stem cell having an anti-prion antibody gene transferred thereinto as the active ingredient and a method of producing the same. These remedies can not only prevent the progress of a prion disease but also contribute to the recovery of nerve dysfunction caused by the disease.
• [EN] TREATMENT OF NEURODEGENERATIVE DISEASES<br/>[FR] TRAITEMENT DE MALADIES NEURODÉGÉNÉRATIVES
  申请人：ICM INST DU CERVEAU ET DE LA MOELLE EPINIERE

  公开号：WO2018091598A2

  公开（公告）日：2018-05-24

  The present invention relates to an agonist of the receptor of 1-[(2R,3R,4S,5R)-5-[[[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxymethyl]-3,4-dihydroxyoxolan-2-yl]pyridin-1-ium-3-carboxylic acid, preferably an agonist of two- pore channel 1 (TPC1) and/or two-pore channel 2 (TPC2), for the treatment and/or prevention of neurodegenerative disorders.