8-chloro-1-cyclopropyl-7-[3-(1,2-dihydroxy-1-methylethyl)pyrrolidin-1-yl]-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | 848615-84-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 8-chloro-1-cyclopropyl-7-[3-(1,2-dihydroxy-1-methylethyl)pyrrolidin-1-yl]-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
• 英文别名: 8-Chloro-1-cyclopropyl-7-[3-(1,2-dihydroxypropan-2-yl)pyrrolidin-1-yl]-6-fluoro-4-oxoquinoline-3-carboxylic acid
• CAS: 848615-84-9
• 化学式: C₂₀H₂₂ClFN₂O₅
• 分子量: 424.856
• InChiKey: YDPSAOAUVKIWDC-UHFFFAOYSA-N

物化性质

• 沸点：
  676.6±55.0 °C(Predicted)
• 密度：
  1.575±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  101
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• [EN] QUINOLONE ANTIBACTERIAL AGENTS<br/>[FR] AGENTS ANTIBACTERIENS A BASE DE QUINOLONE
  申请人：WARNER LAMBERT CO

  公开号：WO2005026165A1

  公开（公告）日：2005-03-24

  Compounds of formula I and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable compositions comprising compounds of formula I. Compounds of formula I as disclosed herein can be used in a variety of applications including use as antibacterial agents.

  公开了式I的化合物及其制备方法。进一步公开了制备式I生物活性化合物的方法，以及包括式I化合物的药用可接受组合物。本文公开的式I化合物可用于各种应用，包括用作抗菌剂。
• Quinolone antibacterial agents
  申请人：Ellsworth Lee Edmund

  公开号：US20050107423A1

  公开（公告）日：2005-05-19

  Compounds of formula I and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable compositions comprising compounds of formula I. Compounds of formula I as disclosed herein can be used in a variety of applications including use as antibacterial agents.

  本文披露了I式化合物及其制备方法。进一步披露了制备具有生物活性的I式化合物的方法，以及含有I式化合物的药学上可接受的组合物的方法。本文所披露的I式化合物可以用于多种应用，包括用作抗菌剂。