sacchathridine A | 1428960-96-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: sacchathridine A
• 英文别名: N'-[7-methoxy-6-methyl-5,8-dioxo-2-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxynaphthalen-1-yl]acetohydrazide
• CAS: 1428960-96-6
• 化学式: C₂₀H₂₄N₂O₉
• 分子量: 436.419
• InChiKey: GQIXMWQEUDYXSA-XZEUZNNKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.34
• 重原子数：
  31.0
• 可旋转键数：
  5.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  163.65
• 氢给体数：
  5.0
• 氢受体数：
  10.0

反应信息

• 作为反应物：
  描述：

  甲醇 、 sacchathridine A 在 盐酸 作用下， 反应 24.0h， 生成 甲基-Alpha-D-吡喃鼠李糖苷
  参考文献：
  名称：

  Sacchathridine A, a Prostaglandin Release Inhibitor from Saccharothrix sp.

  摘要：

  Sacchathridine A (1) was isolated from the fermentation broth of strain Saccharothrix sp. MI559-46F5. The structure was determined as a new naphthoquinone derivative with an acetylhydrazino moiety by a combination of NMR, MS spectral analyses, and chemical degradation. Compound 1 showed inhibitory activity of prostaglandin E-2 release in a concentration-dependent manner from human synovial sarcoma cells, SW982, with an IC50 value of 1.0 mu M, but had no effect on cell growth up to 30 mu M.

  DOI：

  10.1021/np3006327

文献信息

• Sacchathridine A, a Prostaglandin Release Inhibitor from <i>Saccharothrix</i> sp.
  作者：Koichi Nakae、Ikuko Kurata、Fukiko Kojima、Masayuki Igarashi、Masaki Hatano、Ryuichi Sawa、Yumiko Kubota、Hayamitsu Adachi、Akio Nomoto

  DOI：10.1021/np3006327

  日期：2013.4.26

  Sacchathridine A (1) was isolated from the fermentation broth of strain Saccharothrix sp. MI559-46F5. The structure was determined as a new naphthoquinone derivative with an acetylhydrazino moiety by a combination of NMR, MS spectral analyses, and chemical degradation. Compound 1 showed inhibitory activity of prostaglandin E-2 release in a concentration-dependent manner from human synovial sarcoma cells, SW982, with an IC50 value of 1.0 mu M, but had no effect on cell growth up to 30 mu M.