1-[(3R)-1,4-dioxaspiro[4.5]decan-3-yl]-13-methyltetradecan-1-one | 942137-24-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[(3R)-1,4-dioxaspiro[4.5]decan-3-yl]-13-methyltetradecan-1-one
• CAS: 942137-24-8
• 化学式: C₂₃H₄₂O₃
• 分子量: 366.585
• InChiKey: NZLLKMVUXOQQDE-JOCHJYFZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  26
• 可旋转键数：
  13
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-[(3R)-1,4-dioxaspiro[4.5]decan-3-yl]-13-methyltetradecan-1-one 在 potassium tri-sec-butyl-borohydride 作用下， 以 四氢呋喃 为溶剂， 以93%的产率得到(1R)-1-[(3R)-1,4-dioxaspiro[4.5]decan-3-yl]-13-methyltetradecan-1-ol
  参考文献：
  名称：

  An asymmetric synthesis of sulfobacin A

  摘要：

  A facile synthesis of sulfobacin A has been developed starting from (R)-cyclohexylideneglyceraldehyde (11). The key steps in the synthesis are the highly diastereocontrolled allylation of 11 and syn-selective reduction of a ketone derived from 11. The other attractive features are the operational simplicity and the use of inexpensive compounds/reagents. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.03.115
• 作为产物：
  描述：

  1-bromo-12-methyltridecane 在 sodium acetate 、 magnesium 、 pyridinium chlorochromate 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 1-[(3R)-1,4-dioxaspiro[4.5]decan-3-yl]-13-methyltetradecan-1-one
  参考文献：
  名称：

  An asymmetric synthesis of sulfobacin A

  摘要：

  A facile synthesis of sulfobacin A has been developed starting from (R)-cyclohexylideneglyceraldehyde (11). The key steps in the synthesis are the highly diastereocontrolled allylation of 11 and syn-selective reduction of a ketone derived from 11. The other attractive features are the operational simplicity and the use of inexpensive compounds/reagents. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.03.115

文献信息

• An asymmetric synthesis of sulfobacin A
  作者：Anubha Sharma、Sunita Gamre、Subrata Chattopadhyay

  DOI：10.1016/j.tetlet.2007.03.115

  日期：2007.5

  A facile synthesis of sulfobacin A has been developed starting from (R)-cyclohexylideneglyceraldehyde (11). The key steps in the synthesis are the highly diastereocontrolled allylation of 11 and syn-selective reduction of a ketone derived from 11. The other attractive features are the operational simplicity and the use of inexpensive compounds/reagents. (c) 2007 Elsevier Ltd. All rights reserved.