7-[(3R,4R)-3,4-bis[(2-methylpropan-2-yl)oxycarbonylamino]pyrrolidin-1-yl]-1-ethyl-6,8-difluoro-4-oxoquinoline-3-carboxylic acid | 382145-52-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7-[(3R,4R)-3,4-bis[(2-methylpropan-2-yl)oxycarbonylamino]pyrrolidin-1-yl]-1-ethyl-6,8-difluoro-4-oxoquinoline-3-carboxylic acid
• CAS: 382145-52-0
• 化学式: C₂₆H₃₄F₂N₄O₇
• 分子量: 552.575
• InChiKey: LOTJRMUCDXSWNN-IAGOWNOFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  39
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  138
• 氢给体数：
  3
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  7-[(3R,4R)-3,4-bis[(2-methylpropan-2-yl)oxycarbonylamino]pyrrolidin-1-yl]-1-ethyl-6,8-difluoro-4-oxoquinoline-3-carboxylic acid 在 盐酸 作用下， 生成 7-((3R,4R)-3,4-Diamino-pyrrolidin-1-yl)-1-ethyl-6,8-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid; hydrochloride
  参考文献：
  名称：

  Novel quinolone derivatives as potent antibacterials

  摘要：

  Several 7-(3R,4R-N,N'-dialkyl diaminopyrrolidinyl)-substituted quinolones were synthesized and evaluated for antibacterial activities. 5-Amino-7-(3R,4R-N,N'-dimethyldiamino-6,8-difluoro-1,4-dihydro-1-cyclopropyl-4-oxoquinoline-3-carboxylic acid was found to have potent antibacterial activity against gram + ve organisms. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00063-8
• 作为产物：
  描述：

  (R,r)-n-苄基-3,4-反式-(n-boc)-二氨基吡咯烷 在 palladium on activated charcoal 甲酸铵 作用下， 以 甲醇 为溶剂， 生成 7-[(3R,4R)-3,4-bis[(2-methylpropan-2-yl)oxycarbonylamino]pyrrolidin-1-yl]-1-ethyl-6,8-difluoro-4-oxoquinoline-3-carboxylic acid
  参考文献：
  名称：

  Novel quinolone derivatives as potent antibacterials

  摘要：

  Several 7-(3R,4R-N,N'-dialkyl diaminopyrrolidinyl)-substituted quinolones were synthesized and evaluated for antibacterial activities. 5-Amino-7-(3R,4R-N,N'-dimethyldiamino-6,8-difluoro-1,4-dihydro-1-cyclopropyl-4-oxoquinoline-3-carboxylic acid was found to have potent antibacterial activity against gram + ve organisms. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00063-8

文献信息

• Microwave assisted amination of quinolone carboxylic acids: an expeditious synthesis of fluoroquinolone antibacterials
  作者：P.Ganapati Reddy、S Baskaran

  DOI：10.1016/s0040-4039(01)01385-5

  日期：2001.9

  A facile amination of quinolone carboxylic acids to fluoroquinolone antibacterials under microwave irradiation is described.

  描述了在微波辐射下将喹诺酮羧酸容易地胺化为氟喹诺酮抗菌剂。