2-bromo-1-(6-methoxypyridin-3-yl)propan-1-one | 1391089-35-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-bromo-1-(6-methoxypyridin-3-yl)propan-1-one
• CAS: 1391089-35-2
• 化学式: C₉H₁₀BrNO₂
• 分子量: 244.088
• InChiKey: OZHBNEJVZLWGQG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,4,6-三氟苯乙酸 、 2-bromo-1-(6-methoxypyridin-3-yl)propan-1-one 在 三乙胺 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以73%的产率得到5-Hydroxy-4-(6-methoxypyridin-3-yl)-5-methyl-3-(2,4,6-trifluorophenyl)furan-2-one
  参考文献：
  名称：

  A new Knoevenagel-type synthesis of fully substituted γ-hydroxybutenolides

  摘要：

  The synthesis of fully substituted gamma-hydroxybutenolides is possible by a Knoevenagel-type ring condensation of alpha-methyleneketones and alpha-ketoesters under basic conditions. This novel transformation allowed the preparation of di-aryl/heteroaryl substituted hydroxyfuranones, such as 20 and 27, which are important intermediates for pyridazine fungicides. As it turned out, a whole range of different substituents, such as alkyl, cycloalkyl, aryl, heteroaryl and ester groups could be linked to the butenolide scaffold, demonstrating the broad scope of the novel cyclization. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.05.125
• 作为产物：
  描述：

  1-(6-methoxypyridin-3-yl)propan-1-one 在 氢溴酸 、 溴 、 溶剂黄146 作用下， 以80%的产率得到2-bromo-1-(6-methoxypyridin-3-yl)propan-1-one
  参考文献：
  名称：

  A new Knoevenagel-type synthesis of fully substituted γ-hydroxybutenolides

  摘要：

  The synthesis of fully substituted gamma-hydroxybutenolides is possible by a Knoevenagel-type ring condensation of alpha-methyleneketones and alpha-ketoesters under basic conditions. This novel transformation allowed the preparation of di-aryl/heteroaryl substituted hydroxyfuranones, such as 20 and 27, which are important intermediates for pyridazine fungicides. As it turned out, a whole range of different substituents, such as alkyl, cycloalkyl, aryl, heteroaryl and ester groups could be linked to the butenolide scaffold, demonstrating the broad scope of the novel cyclization. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.05.125

文献信息

• [EN] COLONY STIMULATING FACTOR-1 RECEPTOR (CSF-1R) INHIBITORS<br/>[FR] INHIBITEURS DU RÉCEPTEUR DE FACTEUR-1 DE STIMULATION DE COLONIES (CSF-1R)
  申请人：GENZYME CORP

  公开号：WO2017015267A1

  公开（公告）日：2017-01-26

  Compounds of the formulas I and XIII, which are useful as colony stimulating factor-1 receptor inhibitors ("CSF 1R inhibitors").

  I和XIII式化合物，可用作促细胞增殖因子-1受体抑制剂（"CSF 1R抑制剂"）。
• [EN] DEUTERATED COLONY STIMULATING FACTOR-1 RECEPTOR (CSF-1R) INHIBITORS<br/>[FR] INHIBITEURS DEUTÉRÉS DU RÉCEPTEUR DU FACTEUR 1 DE STIMULATION DES COLONIES (CSP-1R)
  申请人：GENZYME CORP

  公开号：WO2022140528A1

  公开（公告）日：2022-06-30

  Disclosed herein are deuterated compounds of the formula which are useful as colony stimulating factor-1 receptor inhibitors ("CSF-1R inhibitors").

  本文披露了一种公式的氘代化合物，它们可用作促细胞增生因子-1受体抑制剂（“CSF-1R抑制剂”）。
• Colony stimulating factor-1 receptor (CSF-1R) inhibitors
  申请人：Genzyme Corporation

  公开号：US11274108B2

  公开（公告）日：2022-03-15

  Compounds of the formulas which are useful as colony stimulating factor-1 receptor inhibitors (“CSF-1R inhibitors”).

  下列式子的化合物 可用作集落刺激因子-1 受体抑制剂（"CSF-1R 抑制剂"）。
• Deuterated colony stimulating factor-1 receptor (CSF-1R) inhibitors
  申请人：Genzyme Corporation

  公开号：US11530216B2

  公开（公告）日：2022-12-20

  Disclosed herein are deuterated compounds of the formula which are useful as colony stimulating factor-1 receptor inhibitors (“CSF-1R inhibitors”).

  本文所公开的是式 可用作集落刺激因子-1 受体抑制剂（"CSF-1R 抑制剂"）。
• COLONY STIMULATING FACTOR-1 RECEPTOR (CSF-1R) INHIBITORS
  申请人：Genzyme Corporation

  公开号：EP3325471A1

  公开（公告）日：2018-05-30