2-Bromo-4-(4-methoxy-phenyl)-1,5-dimethyl-1H-imidazole | 890705-58-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-Bromo-4-(4-methoxy-phenyl)-1,5-dimethyl-1H-imidazole
• CAS: 890705-58-5
• 化学式: C₁₂H₁₃BrN₂O
• 分子量: 281.152
• InChiKey: FPTIOMZJLPIIBZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.17
• 重原子数：
  16.0
• 可旋转键数：
  2.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  27.05
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  2-Bromo-4-(4-methoxy-phenyl)-1,5-dimethyl-1H-imidazole 、 2,6-二溴吡啶 在 四(三苯基膦)钯 正丁基锂 、 三丁基氯化锡 作用下， 以 乙醚 、 正己烷 、 甲苯 为溶剂， 反应 34.5h， 以75%的产率得到2,6-Bis[4-(4-methoxyphenyl)-1,5-dimethylimidazol-2-yl]pyridine
  参考文献：
  名称：

  Shape-Selective Fluorescent Sensing Ensemble Using a Tweezer-Type Metalloreceptor

  摘要：

  A fluorescent sensing ensemble for pyridine-derived compounds is described. The receptor portion of the ensemble is prepared from a bisimidazole pyridine which coordinates copper to form a well-defined cavity. Small heteroaromatic guests such as adenine bind strongly in the cavity. The fluorescent response is provided by a dye which is coordinated to the receptor and quenched by the metal ion. The dye is released upon guest binding providing up to 25-fold fluorescence increases.

  DOI：

  10.1021/ol060641k
• 作为产物：
  描述：

  4-(4-Methoxyphenyl)-1,5-dimethylimidazole 在 N-溴代丁二酰亚胺(NBS) 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 以50%的产率得到2-Bromo-4-(4-methoxy-phenyl)-1,5-dimethyl-1H-imidazole
  参考文献：
  名称：

  Shape-Selective Fluorescent Sensing Ensemble Using a Tweezer-Type Metalloreceptor

  摘要：

  A fluorescent sensing ensemble for pyridine-derived compounds is described. The receptor portion of the ensemble is prepared from a bisimidazole pyridine which coordinates copper to form a well-defined cavity. Small heteroaromatic guests such as adenine bind strongly in the cavity. The fluorescent response is provided by a dye which is coordinated to the receptor and quenched by the metal ion. The dye is released upon guest binding providing up to 25-fold fluorescence increases.

  DOI：

  10.1021/ol060641k