6-Fuoro-N,N-dimethylpyridin-3-amine | 1823624-32-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 6-Fuoro-N,N-dimethylpyridin-3-amine
• 英文别名: 6-fluoro-N,N-dimethylpyridin-3-amine
• CAS: 1823624-32-3
• 化学式: C₇H₉FN₂
• 分子量: 140.16
• InChiKey: PNLGUGDMFMBFKY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  16.1
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H315,H319,H335

文献信息

• FUSED PYRIMIDINE COMPOUNDS AND USE THEREOF
  申请人：MEDIVATION TECHNOLOGIES, INC.

  公开号：US20160068513A1

  公开（公告）日：2016-03-10

  Fused pyrimidine compounds as kinase inhibitors, such as multi-kinase inhibitors, are provided. Fused pyrimidine compounds as IGF-IR inhibitors are provided. Fused pyrimidine compounds that are inhibitors of Trk receptors (e.g., Trk A, Trk B and Trk C) are provided also. The compounds may be used in a method of treating cancer. Pharmaceutical compositions containing a fused pyrimidine compound and a pharmaceutically acceptable carrier are also provided, as are kits containing a fused pyrimidine compound or salt thereof and instructions for use, e.g., in a method of treating cancer.

  提供了作为激酶抑制剂的融合嘧啶化合物，例如多激酶抑制剂。提供了作为IGF-IR抑制剂的融合嘧啶化合物。还提供了抑制Trk受体（例如Trk A，Trk B和Trk C）的融合嘧啶化合物。这些化合物可以用于治疗癌症的方法。还提供了含有融合嘧啶化合物和药用载体的制药组合物，以及包含融合嘧啶化合物或其盐和使用说明的试剂盒，例如用于治疗癌症的方法。
• N-HETEROCYCLIC METHYLPROPYLAMINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND GERMICIDES
  申请人：KUREHA KAGAKU KOGYO KABUSHIKI KAISHA

  公开号：EP1020441A1

  公开（公告）日：2000-07-19

  N-heterocyclicmethylpropylamine derivatives of formula (I): and acid addition salts thereof; wherein R1 represents hydrogen, halogen, alkyl, alkenyl, halogenated alkyl, alkoxy, halogenated alkoxy, hydroxyl, cyano, nitro, phenyl optionally having a substituent on a ring thereof or phenoxy; n represents an integer of 0-5; R2 represents a heterocycle containing at least one nitrogen atom as the hetero atom and optionally having a substituent on a ring thereof; and R3 represents hydrogen or C1-C5 alkyl.

  式(I)的 N-杂环甲基丙胺衍生物： 及其酸加成盐； 其中 R1 代表氢、卤素、烷基、烯基、卤代烷基、烷氧基、卤代烷氧基、羟基、氰基、硝基、可选择在其环上具有取代基的苯基或苯氧基；n 代表 0-5 的整数；R2 代表至少含有一个氮原子作为杂原子并可选择在其环上具有取代基的杂环；以及 R3 代表氢或 C1-C5 烷基。
• N-(HETEROCYCLE-METHYL)ALKYLAMINE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND BACTERICIDE
  申请人：Kureha Chemical Industry Co., Ltd.

  公开号：EP1391450A1

  公开（公告）日：2004-02-25

  A N-heterocyclicmethyl-alkylamine derivative according to the present invention is a N-heterocyclicmethyl-alkylamine derivative represented by the following general formula (I): or an acid addition salt thereof. [in the formula, R1 represents a heterocycle which has at least one nitrogen atom as a hetero atom and may have a substituent on a ring; R2 represents a hydrogen or the like; R3 represents an alkyl group having a carbon number of 1 to 5 or the like; R4 represents an alkyl group having a carbon number of 1 to 5 or the like; when R4 is an alkyl group having a carbon number of 1 to 5 or a halogenated alkyl group having a carbon number of 1 to 5, carbon atoms in R3 and R4 may be bonded to form a ring structure; m represents an integer of 1 to 3; R5 represents a cycloalkyl group or the like described by the following formula (III): (in the formula, Y and Z each represents a hydrogen atom or the like, the letter p represents an integer of 2 to 5, and the groups described by CYZ may be each the same or different), when m is 1 and R4 is a hydrogen atom, R5 is a cycloalkyl group describedby the foregoing formula (III).]

  根据本发明，N-杂环甲基-烷基胺衍生物是由以下通式（I）代表的 N-杂环甲基-烷基胺衍生物： 或其酸加成盐。 [式中，R1 代表杂环，该杂环至少有一个氮原子作为杂原子，并可在环上有取代基；R2 代表氢或类似物；R3 代表碳原子数为 1 至 5 的烷基或类似物；R4 代表碳原子数为 1 至 5 的烷基或类似物；当 R4 是碳原子数为 1 至 5 的烷基或碳原子数为 1 至 5 的卤代烷基时，R3 和 R4 中的碳原子可以键合形成环状结构；m 代表 1 至 3 的整数；R5 代表下式（III）所述的环烷基或类似基团： (式中，Y 和 Z 分别代表氢原子或类似物，字母 p 代表 2 至 5 的整数，CYZ 所述基团可以相同或不同)，当 m 为 1 且 R4 为氢原子时，R5 为前式(III)所述的环烷基]。
• N-(heterocycle-methyl)alkylamine derivative, process for producing the same, and bactericide
  申请人：Ito Atsushi

  公开号：US20050101783A1

  公开（公告）日：2005-05-12

  A N-heterocyclicmethyl-alkylamine derivative according to the present invention is a N-heterocyclicmethyl-alkylamine derivative represented by the following general formula (I): or an acid addition salt thereof. [in the formula, R 1 represents a heterocycle which has at least one nitrogen atom as a hetero atom and may have a substituent on a ring; R 2 represents a hydrogen or the like; R 3 represents an alkyl group having a carbon number of 1 to 5 or the like; R 4 represents an alkyl group having a carbon number of 1 to 5 or the like; when R 4 is an alkyl group having a carbon number of 1 to 5 or a halogenated alkyl group having a carbon number of 1 to 5, carbon atoms in R 3 and R 4 may be bonded to form a ring structure; m represents an integer of 1 to 3; R 5 represents a cycloalkyl group or the like described by the following formula (III): (in the formula, Y and Z each represents a hydrogen atom or the like, the letter p represents an integer of 2 to 5, and the groups described by CYZ may be each the same or different), when m is 1 and R 4 is a hydrogen atom, R 5 is a cycloalkyl group described by the foregoing formula (III).]

  根据本发明，N-杂环甲基-烷基胺衍生物是由以下通式（I）代表的 N-杂环甲基-烷基胺衍生物： 或其酸加成盐。 [式中，R 1 代表至少有一个氮原子作为杂原子的杂环，并可在环上有取代基；R 2 代表氢或类似物；R 3 代表碳原子数为 1 至 5 的烷基或类似物； R 4 代表碳原子数为 1 至 5 的烷基或类似物；当 R 4 是碳原子数为 1 至 5 的烷基或碳原子数为 1 至 5 的卤代烷基时，R 3 和 R 4 中的碳原子可以键合形成环状结构；m 代表 1 至 3 的整数；R 5 代表下式（III）所述的环烷基或类似基团： (式中，Y 和 Z 分别代表氢原子或类似物，字母 p 代表 2 至 5 的整数，CYZ 所述基团可以相同或不同），当 m 为 1 且 R 4 是氢原子时，R 5 是前述式 (III) 所述的环烷基]。
• US6271385B1
  申请人：——

  公开号：US6271385B1

  公开（公告）日：2001-08-07