benzyl 2-methylenepent-4-enoate | 1373556-15-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzyl 2-methylenepent-4-enoate
• 英文别名: Benzyl 2-methylidenepent-4-enoate
• CAS: 1373556-15-0
• 化学式: C₁₃H₁₄O₂
• 分子量: 202.253
• InChiKey: MOHXOTLWRYTSKQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  二溴氟乙酸乙酯 、 benzyl 2-methylenepent-4-enoate 在 三甲基氯硅烷 、 lithium chloride 、 锌 作用下， 以 四氢呋喃 、 二甲基亚砜 为溶剂， 以50%的产率得到1-benzyl 2-ethyl 1-allyl-2-fluorocyclopropane-1,2-dicarboxylate
  参考文献：
  名称：

  One-Step Synthesis of Highly Functionalized Monofluorinated Cyclopropanes from Electron-Deficient Alkenes

  摘要：

  The unique combination of Zn/LiCl allowed generation of reactive zinc enolate from ethyl dibromofluoroacetate. This fluorinated enolate reacts efficiently with a wide range of functionalized electron-deficient alkenes to afford the corresponding monofluorinated cyclopropylcarboxylates in good yields.

  DOI：

  10.1021/ol300687s
• 作为产物：
  描述：

  2-methylenepent-4-enoic acid 、 溴甲苯 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 72.25h， 以89%的产率得到benzyl 2-methylenepent-4-enoate
  参考文献：
  名称：

  One-Step Synthesis of Highly Functionalized Monofluorinated Cyclopropanes from Electron-Deficient Alkenes

  摘要：

  The unique combination of Zn/LiCl allowed generation of reactive zinc enolate from ethyl dibromofluoroacetate. This fluorinated enolate reacts efficiently with a wide range of functionalized electron-deficient alkenes to afford the corresponding monofluorinated cyclopropylcarboxylates in good yields.

  DOI：

  10.1021/ol300687s

文献信息

• Method of making alternating copolymers of isobutylene type monomers
  申请人：——

  公开号：US20030171515A1

  公开（公告）日：2003-09-11

  A method of making a copolymer composition containing a copolymer, which includes the steps of (a) providing a donor monomer composition that includes an isobutylene type monomer; (b) mixing the donor monomer composition with an ethylenically unsaturated monomer composition that includes one or more ethylenically unsaturated acceptor monomers, and is substantially free of maleate type monomers and fumarate type monomers, and (c) polymerizing the mixture resulting from step (b) in the presence of a free radical polymerization initiator. The polymerization is carried out in the substantial absence of Lewis acids and/or transition metals. The isobutylene type monomer is present at a molar excess of at least 10 mol % based on the molar concentration of monomers in the ethylenically unsaturated monomer composition. The ethylenically unsaturated acceptor monomers are present in an amount of at least 15 mol % of the total monomer composition.

  一种制备共聚物组合物的方法，包括以下步骤：(a)提供包括异丁烯型单体的供体单体组合物；(b)将供体单体组合物与包括一种或多种乙烯基不饱和受体单体且基本上不含马来酸酯型单体和富马酸酯型单体的乙烯基不饱和单体组合物混合；(c)在自由基聚合引发剂的存在下聚合步骤(b)得到的混合物。聚合在基本上不含路易斯酸和/或过渡金属的情况下进行。异丁烯型单体的摩尔过量至少为乙烯基不饱和单体组合物中单体的摩尔浓度的10摩尔％。乙烯基不饱和受体单体的量至少为总单体组合物的15摩尔％。
• Skeletal Editing Approach to Bridge-Functionalized Bicyclo[1.1.1]pentanes from Azabicyclo[2.1.1]hexanes
  作者：Brandon A. Wright、Anastassia Matviitsuk、Michael J. Black、Pablo García-Reynaga、Luke E. Hanna、Aaron T. Herrmann、Michael K. Ameriks、Richmond Sarpong、Terry P. Lebold

  DOI：10.1021/jacs.3c02616

  日期：2023.5.24

  Azabicyclo[2.1.1]hexanes (aza-BCHs) and bicyclo[1.1.1]pentanes (BCPs) have emerged as attractive classes of sp3-rich cores for replacing flat, aromatic groups with metabolically resistant, three-dimensional frameworks in drug scaffolds. Strategies to directly convert, or “scaffold hop”, between these bioisosteric subclasses through single-atom skeletal editing would enable efficient interpolation within

  氮杂双环[2.1.1]己烷 (aza-BCH) 和双环[1.1.1]戊烷 (BCP) 已成为富含sp 3的有吸引力的核心类别，用于在药物中用耐代谢的三维框架取代扁平芳香基团脚手架。通过单原子骨架编辑在这些生物电子等排子类之间直接转换或“支架跳跃”的策略将能够在这个有价值的化学空间内进行有效的插值。在此，我们描述了一种通过脱氮骨架编辑在 aza-BCH 和 BCP 核心之间“支架跳跃”的策略。光化学[2+2]环加成用于制备多功能化的aza-BCH框架，与随后的脱氨基步骤相结合以提供桥功能化的BCP，目前很少有合成解决方案。模块化序列提供了对制药相关的各种特权桥式自行车的访问。
• Ocular lens material
  申请人：Menicon Co., Ltd.

  公开号：EP0843184B1

  公开（公告）日：2004-03-03
• METHOD OF MAKING ALTERNATING COPOLYMERS OF ISOBUTYLENE TYPE MONOMERS
  申请人：PPG Industries Ohio, Inc.

  公开号：EP1474457A1

  公开（公告）日：2004-11-10
• US5118537A
  申请人：——

  公开号：US5118537A

  公开（公告）日：1992-06-02