{2-Methyl-1-[2-methyl-prop-(E)-ylideneamino]-propyl}-phosphonic acid diethyl ester | 68544-41-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物
• 英文名称: {2-Methyl-1-[2-methyl-prop-(E)-ylideneamino]-propyl}-phosphonic acid diethyl ester
• CAS: 68544-41-2
• 化学式: C₁₂H₂₆NO₃P
• 分子量: 263.317
• InChiKey: VXEBBBVITCFQEA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.96
• 重原子数：
  17.0
• 可旋转键数：
  8.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  47.89
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  {2-Methyl-1-[2-methyl-prop-(E)-ylideneamino]-propyl}-phosphonic acid diethyl ester 在 盐酸 、 水 、 sodium hydroxide 作用下， 以 水 为溶剂， 生成 diethyl 1-amino-2-methylpropylphosphonate
  参考文献：
  名称：

  Molecular iodine: An efficient catalyst for the one-pot synthesis of primary 1-aminophosphonates

  摘要：

  A new and convenient procedure has been developed for the one-pot synthesis of different types of primary 1-aminophosphonates from aldehydes/ketones, HMDS and diethyl phosphite using I-2 as an inexpensive, non-toxic, non-metallic and readily available catalyst. These reactions proceeded under solvent-free conditions and produced the desired products in high yields.

  DOI：

  10.1007/bf03245883
• 作为产物：
  描述：

  异丁醛 、 亚磷酸二乙酯 在 碘 、 六甲基二硅氮烷 作用下， 反应 0.33h， 生成 {2-Methyl-1-[2-methyl-prop-(E)-ylideneamino]-propyl}-phosphonic acid diethyl ester
  参考文献：
  名称：

  Molecular iodine: An efficient catalyst for the one-pot synthesis of primary 1-aminophosphonates

  摘要：

  A new and convenient procedure has been developed for the one-pot synthesis of different types of primary 1-aminophosphonates from aldehydes/ketones, HMDS and diethyl phosphite using I-2 as an inexpensive, non-toxic, non-metallic and readily available catalyst. These reactions proceeded under solvent-free conditions and produced the desired products in high yields.

  DOI：

  10.1007/bf03245883